Adverse event risks and prognostic factors associated with endoscopic laryngopharyngeal surgery for superficial head and neck cancer after chemoradiotherapy.

Sakiko Naito, Hayato Yamaguchi, Masakatsu Fukuzawa, Isaku Okamoto, Kiyoaki Tsukahara, Takao Itoi

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Article in International journal of clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Sakiko NaitoDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. rin.sooooo.sweety@gmail.com.ORCID http://orcid.org/0000-0002-7533-1061

Hayato YamaguchiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Masakatsu FukuzawaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Isaku OkamotoDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1, Nishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan.

Kiyoaki TsukaharaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1, Nishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan.

Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic laryngopharyngeal surgery (ELPS) is an organ-preserving treatment for superficial head and neck squamous cell carcinoma (sHNSCC). While ELPS shows favorable outcomes in primary and metachronous lesions, its role as salvage treatment following chemoradiotherapy (CRT) remains unclear. We evaluated the clinical outcomes of salvage ELPS and factors associated with adverse events (AEs) and prognosis.

methodsAmong 136 patients undergoing ELPS between 2014 and 2024, we retrospectively analyzed 17 diagnosed with sHNSCC following CRT. Patients were categorized into salvage and metachronous groups, and clinical characteristics, treatment outcomes, AEs, and survival were compared.

resultsThe en bloc resection rate was 100%. AEs occurred in 47.1% of patients and were more frequent in the salvage group than in the metachronous group (70.0% vs. 14.3%, p=0.024). Body mass index (BMI) <18.5 kg/m

conclusionSalvage ELPS for sHNSCC was associated with a higher AE risk but showed long-term survival outcomes comparable to metachronous ELPS. Nutritional status, particularly low BMI, is a key determinant of safety and prognosis. These findings support the feasibility of ELPS as an organ-preserving strategy and emphasize the importance of careful patient selection and nutritional assessment in salvage settings.

Indexed as

ELPSHead and neck cancerSalvage

Identifiers

PMID42762422

DOI10.1200/JCO.2009.25.4680

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