Evidence map›Paper›PMID 42762414›Full record

ArticleMolecular and cellular biochemistry2026

Regulation of the murine preadipocytes differentiation by bitter taste receptor Tas2r108 and Tas2r126.

Eisuke Kato, Shota Oshima, Yusuke Adachi, Reitaro Imai

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eisuke KatoResearch Faculty of Agriculture, Hokkaido University, Sapporo, Japan. eikato@eis.hokudai.ac.jp.ORCID http://orcid.org/0000-0001-9322-8589
Shota OshimaGraduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Yusuke AdachiGraduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Reitaro ImaiGraduate School of Agriculture, Hokkaido University, Sapporo, Japan.

Funding

Japan Society for the Promotion of Science 23K05107
6 · The paper itself

Abstract

Taste 2 receptors (T2Rs) are known as receptors for sensing bitterness, but their gene expressions are observed in various extraoral tissues. T2Rs in adipocytes have attracted attention because bitter compounds influence lipid accumulation. However, the role of T2Rs in adipocytes has not been extensively investigated. This study investigated the functions of Tas2r108 and Tas2r126 in preadipocyte differentiation. Overexpression of Tas2r108 or Tas2r126 inhibited the differentiation of 3T3-L1 cells and mouse primary preadipocytes. Similarly, knockdown of Tas2r108 suppressed the differentiation of these cells. Consistent with the knockdown results, stimulation with T2R agonists during the differentiation of 3T3-L1 cells enhanced adipogenesis. Mechanistic analysis revealed that the suppressed differentiation by T2R overexpression involves the downregulation of Cebpb, while T2R knockdown involves the upregulation of Nr4a2 and Nr4a3 and downregulation of Egr2. Analysis with T2R agonists revealed that T2Rs in preadipocytes couple with inhibitory G-protein to downregulate intracellular cAMP concentrations, which works through ERK to enhance adipogenesis. These results demonstrate the regulation of adipocyte differentiation by T2Rs and suggest that bitter compounds enhance adipogenesis via T2Rs.

Indexed as

AdipocytesAdipogenesisCell DifferentiationReceptors, G-Protein-Coupled3T3-L1 CellsAnimalsCCAAT-Enhancer-Binding Protein-betaEarly Growth Response Protein 2MiceTaste Receptors, Type 2CCAAT-Enhancer-Binding Protein-betaCebpb protein, mouseEarly Growth Response Protein 2Egr2 protein, mouseReceptors, G-Protein-CoupledTaste Receptors, Type 2AdipocyteAdipogenesisBitter taste receptorObesityTas2r108Tas2r126Taste 2 receptor

Identifiers

PMID42762414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.