ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Early biochemical and microvascular alterations in asymmetric nonglaucomatous pseudoexfoliation syndrome: a multimodal aqueous humor, serum, OCTA, and CVI analysis.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeTo evaluate serum and aqueous humor levels of hypoxia-inducible factor-1 alpha (HIF-1α), growth differentiation factor-15 (GDF-15), and fatty acid-binding protein-4 (FABP-4) in asymmetric nonglaucomatous pseudoexfoliation syndrome (PEX).
methodsThis cross-sectional comparative study included 153 eyes of 102 participants. Fifty-one asymmetric PEX patients contributed both PEX-positive (PEX+) and fellow PEX-negative (PEX-) eyes, while 51 eyes of age-matched cataract patients without PEX served as controls. Serum and aqueous humor samples were collected immediately before cataract surgery and analyzed for HIF-1α, GDF-15, and FABP-4 levels. Optical coherence tomography angiography (OCTA)-derived peripapillary vascular parameters (whole radial peripapillary capillaries vessel density [WRPC], inside disc radial peripapillary capillaries vessel density [IDRPC], peripapillary radial peripapillary capillaries vessel density [PPRPC]), peripapillary retinal nerve fiber layer (pRNFL) thickness, and choroidal vascularity index (CVI) measurements were evaluated.
resultsSerum HIF-1α, GDF-15, and FABP-4 levels were significantly higher in PEX patients compared with controls (all p<0.05). Aqueous HIF-1α levels were significantly elevated in both groups. PEX+ eyes demonstrated significantly higher aqueous FABP-4 levels compared with both controls and fellow PEX- eyes. OCTA analysis revealed significantly reduced WRPC, IDRPC, PPRPC, CVI, and pRNFL values in PEX+ eyes. Fellow PEX- eyes also exhibited significant microvascular and choroidal alterations compared with control cataract patients.
conclusionAmong the evaluated biomarkers, aqueous FABP-4 may be more closely associated with clinically affected eyes and microvascular impairment.
Identifiers
42762312What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.