Evidence map›Paper›PMID 42762310›Full record

ArticleEuropean journal of clinical pharmacology2026

Case-based pharmacotherapeutic learning structured around the prescribing optimization method and the WHO 6-step model: Medical students' views from an exploratory questionnaire study.

Massimiliano Carifi, Fabio Furchì, Naldy Parodi López, Joost D Piët, Jelle Tichelaar, Fabrizio De Ponti, Susanna M Wallerstedt

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Article in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Massimiliano CarifiPharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0009-0003-8962-5380
Fabio FurchìPharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Naldy Parodi LópezDepartment of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Box 431, Gothenburg, SE-405 30, Sweden.
Joost D PiëtDepartment of Internal Medicine, Unit Pharmacotherapy, Amsterdam UMC, Vrije Universiteit, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
Jelle TichelaarDepartment of Internal Medicine, Unit Pharmacotherapy, Amsterdam UMC, Vrije Universiteit, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
Fabrizio De PontiPharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Susanna M WallerstedtDepartment of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Box 431, Gothenburg, SE-405 30, Sweden. susanna.wallerstedt@pharm.gu.se.ORCID http://orcid.org/0000-0001-7238-1680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePharmacotherapy is a core competence for physicians and case-based learning is a valuable teaching method for developing this competence. This study explored medical students' views on structuring pharmacotherapeutic education around either the Prescribing Optimization Method (POM), starting from the medication list, or the World Health Organization (WHO) 6-Step Model, starting from the patient's presentation.

methodsStudents who had experienced both the POM and the WHO 6-Step Model, featuring cases involving multiple medications, during an elective pharmacology clerkship at the University of Bologna, were invited to complete an anonymous questionnaire. Participants rated their agreement with a statement regarding the usefulness of each structure for developing pharmacotherapeutic knowledge (1 = strongly disagree, 5 = strongly agree), indicated their preferred structure, and provided comments explaining their choice and contexts in which each structure was considered useful.

resultsAll students participating in the clerkship shared their views (n = 27). Their ratings of each structure's usefulness for developing pharmacotherapeutic knowledge were 4.3 ± 0.8 (POM) and 4.1 ± 1.1 (WHO). Thirteen students preferred the POM, often referring to its comprehensive medication focus in the context of polypharmacy, and the value of such guidance in the undergraduate learning process. Twelve students preferred the WHO 6-Step Model, often referring to its alignment with clinical practice and the learning it offers for their future professional role.

conclusionStudents perceived both structures as useful for pharmacotherapeutic learning; future studies should examine whether these approaches improve prescribing competence or therapeutic reasoning performance.

Indexed as

Problem-Based LearningStudents, MedicalClinical ClerkshipClinical CompetenceDrug PrescriptionsFemaleHumansMaleSurveys and QuestionnairesEducationMedical programmePharmacotherapyPolypharmacyPrescribingTeaching

Identifiers

PMID42762310
PMCPMC13589751

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.