β-cyclodextrin-kneaded Coccinia grandis thermosensitive mucoadhesive buccal gel: factorial optimization and preclinical evaluation in cisplatin-induced pica.

Shubham N Kanawade, Ravindra B Laware, Dhruv R Vikhe, Vishwas B Patare, Rahul R Kunkulol, Salim G Patel

Abstract read

In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shubham N KanawadePravara Institute of Medical Sciences (Deemed to be University), College of Pharmaceutical Sciences, A/p: Loni Tal: Rahata Dist: Ahmednagar, Maharashtra, 413736, India. shubham.kanawade@pmtpims.org.ORCID http://orcid.org/0009-0001-7402-3366

Ravindra B LawarePravara Institute of Medical Sciences (Deemed to be University), College of Pharmaceutical Sciences, A/p: Loni Tal: Rahata Dist: Ahmednagar, Maharashtra, 413736, India.ORCID http://orcid.org/0000-0002-4370-1582

Dhruv R VikhePravara Institute of Medical Sciences (Deemed to be University), A/p: Loni Tal: Rahata Dist: Ahmednagar, Maharashtra, 413736, India.ORCID http://orcid.org/0009-0006-7862-6654

Vishwas B PatarePravara Institute of Medical Sciences (Deemed to be University), College of Pharmaceutical Sciences, A/p: Loni Tal: Rahata Dist: Ahmednagar, Maharashtra, 413736, India.ORCID http://orcid.org/0009-0001-5257-3471

Rahul R KunkulolPravara Institute of Medical Sciences (Deemed to be University), Dr. Balasaheb Vikhe Patil Rural Medical College, A/p: Loni Tal: Rahata Dist: Ahmednagar, Maharashtra, 413736, India.ORCID http://orcid.org/0000-0002-5903-6185

Salim G PatelPravara Institute of Medical Sciences (Deemed to be University), College of Pharmaceutical Sciences, A/p: Loni Tal: Rahata Dist: Ahmednagar, Maharashtra, 413736, India.ORCID http://orcid.org/0000-0001-7984-1811

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To develop and optimize a Coccinia grandis (L.) Voigt root extract-loaded thermosensitive mucoadhesive buccal gel as a preclinical approach for antiemetic delivery. Thermosensitive gels containing an extract-β-cyclodextrin kneaded preparation were prepared using Poloxamer 407 and Carbopol 934P. Apparent solubility of the kneaded preparation was compared with that of the untreated extract. A 3

Indexed as

Buccal in situ gelCarbopol 934PChemotherapy-induced nausea and vomitingCoccinia grandisEx vivo permeationMucoadhesivePoloxamer 407

Identifiers

PMID42762306

DOI10.1038/s41598-024-52413-9

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.