Evidence map›Paper›PMID 42762301›Full record

ArticlePediatric radiology2026

Predictors of clinically significant hemorrhage following ultrasound-guided percutaneous renal biopsy in pediatric patients.

Rajkumar Meena, Nick Barrowman, Anne Tsampalieros, Gali Shapira-Zaltsberg

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Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Rajkumar MeenaDepartment of Medical Imaging, CHEO, Ottawa K1H8L6, Canada.
Nick BarrowmanUniversity of Ottawa, Ottawa, Canada.
Anne TsampalierosUniversity of Ottawa, Ottawa, Canada.
Gali Shapira-ZaltsbergDepartment of Medical Imaging, CHEO, Ottawa K1H8L6, Canada. GShapira@cheo.on.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUltrasound-guided percutaneous renal biopsy is a cornerstone in the evaluation of pediatric kidney disease, with post-biopsy hemorrhage being the most common complication. Multiple predictors of post-biopsy bleeding have been identified in the adult population; however, data on risk factors in children is limited.

objectiveThe purpose of our study is to determine any risk factors of post-biopsy hemorrhage in children. MATERIALS AND

methodsThis IRB-approved retrospective study included pediatric patients who had native or transplant renal biopsy between 2010-2024. The primary outcomes included decrease of hemoglobin of >15 g/L measured 4-6 h post biopsy and/or presence of a sizable perinephric hematoma (defined as ≥5 mL) measured on immediate post-biopsy ultrasound. The association between presence of hematoma and significant change in Hb was assessed, and the association of 12 different preselected risk factors with these co-primary outcomes was analyzed.

resultsAmong 207 patients included (median age 11 years [IQR, 7-14]), 170 (82%) underwent native kidney biopsy and 37 (18%) transplant kidney biopsy. A post-biopsy hemoglobin decrease ≥15 g/L occurred in 23 patients (11%; 95% CI, 8-16%), and 27 (13%; 95% CI, 9-18%) developed a sizable perinephric hematoma. A hematoma ≥5 mL on immediate post-procedural imaging was associated with a hemoglobin decrease ≥15 g/L (OR 4.6, 95% CI 1.5-13.4; P=0.004). No other factors were significantly associated with hemoglobin decline or hematoma after correction for multiple testing.

conclusionImmediate post-biopsy ultrasound findings may help predict clinically significant post-biopsy hemorrhage, while no other risk factors were identified.

Indexed as

HemorrhageKidneyRenal biopsyUltrasound

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