Evidence map›Paper›PMID 42762280›Full record

ArticleJournal of neuro-oncology2026

Single-stage tumor resection and immediate CAD/CAM-assisted cranio-orbital reconstruction for spheno-orbital meningiomas: a standardized surgical workflow and outcome analysis.

Panagiotis Fistouris, Elisa Ventura, Ahmad Abdullah Altayyar, Ali Alanesi, Manou Overstijns, Roland Roelz, Benjamin Brokinkel, Uta Schick

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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Panagiotis FistourisDepartment of Neurosurgery, Clemenshospital Muenster, Academic Hospital of Muenster University, Muenster, Germany. notisfis@hotmail.com.
Elisa VenturaDepartment of Neurosurgery, Clemenshospital Muenster, Academic Hospital of Muenster University, Muenster, Germany.
Ahmad Abdullah AltayyarDepartment of Neurosurgery, Clemenshospital Muenster, Academic Hospital of Muenster University, Muenster, Germany.
Ali AlanesiDepartment of Neurosurgery, Clemenshospital Muenster, Academic Hospital of Muenster University, Muenster, Germany.
Manou OverstijnsDepartment of Neurosurgery, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany.
Roland RoelzDepartment of Neurosurgery, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany.
Benjamin BrokinkelDepartment of Neurosurgery, Clemenshospital Muenster, Academic Hospital of Muenster University, Muenster, Germany.
Uta SchickDepartment of Neurosurgery, Clemenshospital Muenster, Academic Hospital of Muenster University, Muenster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpheno-orbital meningiomas (SOMs) are surgically challenging lesions characterized by tumor infiltration and hyperostosis of the sphenoid wing and orbit. Surgical treatment requires tumor resection, drilling of hyperostotic bone, orbital decompression and skull base reconstruction. Traditionally, reconstruction has been performed either free hand or as a delayed second-stage procedure, often resulting in suboptimal skull and facial symmetry. Single-stage resection with immediate CAD/CAM-assisted reconstruction offers a feasible alternative but requires meticulous preoperative planning and a standardized surgical workflow.

methodsIn this retrospective study of 34 patients with SOMs, we present our institutional standardized protocol for preoperative CAD/CAM planning and single-stage tumor resection with immediate skull reconstruction technique. Clinical, functional and radiological outcomes were also assessed.

resultsExopthalmos was the predominant presenting symptom. Gross-total resection was achieved in 73.5% of cases, resulting in a reduction of exophthalmos in 85% of patients and improvement of visual acuity in approximately 70%. However, postoperative amaurosis occurred in 8.8% and transient diplopia in 55.9%. CAD/CAM implants demonstrated appropriate intraoperative fit without major implant-related complications and with preservation of orbital and facial symmetry.

conclusionSingle-stage resection with immediate CAD/CAM-assisted skull reconstruction for SOMs is feasible, safe and reproducible. The standardized workflow by combining tumor resection and patient-specific reconstruction within a single-stage procedure may offer practical advantages in the overall surgical pathway.

Indexed as

Meningeal NeoplasmsMeningiomaNeurosurgical ProceduresOrbital NeoplasmsPlastic Surgery ProceduresSphenoid BoneAdultAgedComputer-Aided DesignFemaleFollow-Up StudiesHumansMaleMiddle AgedOrbitRetrospective StudiesCAD/CAM-assistedSingle-stage surgerySkull base reconstructionSpheno-orbital meningioma

Identifiers

PMID42762280

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