Evidence map›Paper›PMID 42762242›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2026

Accelerated TMS is associated with changes of subgenual cingulate-default mode network coupling in depression: an observational 7 Tesla fMRI study.

Tobias Bracht, Pascal Borel, Stefan Dendorfer, Leila M Soravia, Kristina Adorjan, Sebastian Walther, Andrea Federspiel, Roland Wiest, Gianluca A Florineth, Niklaus Denier

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Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tobias BrachtCompetence Centre for Interventional Psychiatry and Augmented Psychotherapy, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. tobias.bracht@unibe.ch.ORCID https://orcid.org/0000-0002-9903-8564
Pascal BorelCompetence Centre for Interventional Psychiatry and Augmented Psychotherapy, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Stefan DendorferCompetence Centre for Interventional Psychiatry and Augmented Psychotherapy, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Leila M SoraviaCompetence Centre for Interventional Psychiatry and Augmented Psychotherapy, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Kristina AdorjanCompetence Centre for Interventional Psychiatry and Augmented Psychotherapy, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Sebastian WaltherDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Andrea FederspielTranslational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland.
Roland WiestTranslational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland.
Gianluca A FlorinethCompetence Centre for Interventional Psychiatry and Augmented Psychotherapy, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Niklaus DenierCompetence Centre for Interventional Psychiatry and Augmented Psychotherapy, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccelerated transcranial magnetic stimulation (aTMS) is an effective treatment for depression, but its neurobiological mechanisms of action remain to be elucidated. This study used high-resolution 7-Tesla MRI to investigate changes in resting-state functional connectivity (rs-FC) of the subgenual anterior cingulate cortex (sgACC) following a treatment series of aTMS. We hypothesized a decrease in sgACC rs-FC with key cortical regions of the default mode network (DMN), reflecting a downregulation of a network that is overactive in depression.

methodsTwenty-two patients with current depression underwent 7-Tesla MRI scans before and after a two-week aTMS treatment series (24,000 pulses) targeting the left dorsolateral prefrontal cortex. Fourteen healthy participants were also scanned twice as a control group. Longitudinal changes in sgACC seed-based rs-FC were compared between groups. Furthermore, group differences were assessed at baseline and at follow-up. Exploratory correlations between longitudinal changes in sgACC rs-FC, depression severity, mindfulness, and affect were also evaluated.

resultsThere was a reduction in rs-FC between the sgACC and bilateral precunei, and between sgACC and left frontal pole in patients receiving aTMS. At baseline, patients had increased rs‑FC between the sgACC and a cluster including the left precuneus and a cluster in the right superior frontal gyrus. Exploratory correlations suggest an association between sgACC-precunei rs-FC changes and mindfulness (p = 0.008, uncorrected for multiple comparisons), while no associations were found with depression severity or affect.

conclusionsTreatment with aTMS is associated with a reduction in rs‑FC between the sgACC and the DMN. Exploratory correlations with mindfulness warrant replication in larger, independent samples.

Indexed as

Accelerated TMSAnterior cingulate cortexDepressionNeuroplasticity

Identifiers

PMID42762242

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