ArticleEuropean archives of psychiatry and clinical neuroscience2026
Peripheral immune-cell bioenergetics in acute and stable schizophrenia.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionImmune and metabolic abnormalities are implicated in schizophrenia, but their functional integration remains unclear.
methodsWe measured PBMC bioenergetics by Seahorse extracellular flux analysis in healthy controls, acutely ill antipsychotic-naive patients, and stable patients receiving olanzapine or risperidone/paliperidone.
resultsAcute schizophrenia showed increased glycolytic ATP production and an altered PBMC bioenergetic phenotype, without significant differences in composite mitochondrial integrity indices. Glycolytic measures were lower in stable treated patients, particularly under olanzapine, although treatment and illness-state effects cannot be separated. Neither plasma nor unstimulated PBMC culture-supernatant cytokines differed after FDR correction.
conclusionPBMC bioenergetic profiling may provide a hypothesis-generating readout of acute-state-associated metabolic reprogramming.
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