ArticleExperimental physiology2026
Effects of 1 Gray radiation on the biophysical properties of the tibia and femur from hindlimb-suspended rats.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Long-term space travel (e.g. travel to Mars) will greatly exceed the recommended lifetime radiation dose of 600 millisieverts (mSv) and have a detrimental effect on skeletal fragility. Our objective was to determine if 1 Gray (GY) radiation impacts the biomechanical properties of the tibia and femur from rats under microgravity. Hindlimb-suspended male Sprague-Dawley rats were irradiated (IR) with 1 GY (+IR) or used as control (-IR); after 4 weeks they were sacrificed to obtain the femur and tibia. Using the three-point bending technique, we found radiation had no effect on the flexure force/bending and stiffness of the femur. However, the tibias from the +IR rats demonstrated 37% less flexure force/bending and stiffness than -IR rats. Bone elemental analysis was determined using a scanning electron microscope equipped with energy dispersive spectroscopy; there was no difference in the calcium/phosphorus ratio between +IR and -IR groups. This study provides pilot data which suggest that low dose radiation exposure has a greater impact on the smaller hindlimb bones from hindlimb-suspended rats.
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