Evidence map›Paper›PMID 42762084›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2026

Office Blood Pressure and Arteriolosclerosis in Biopsy-Proven Glomerulonephritis: Association With Renal Function Decline and Clinical Outcomes.

Antonietta Gigante, Alice Trombacco, Giulia Galanti, Chiara Pellicano, Georgia Sorato, Rosa Cascone, Edoardo Rosato, Konstantinos Giannakakis, Rosario Cianci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonietta GiganteDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Alice TrombaccoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Giulia GalantiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Chiara PellicanoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Georgia SoratoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Rosa CasconeDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Edoardo RosatoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Konstantinos GiannakakisDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, Pathological Anatomy, Sapienza University of Rome, Rome, Italy.
Rosario CianciDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension is a major determinant of chronic kidney disease progression, yet the relationship between standardized office blood pressure measurements (OBPM), chronic vascular lesions, and prognosis in biopsy-proven glomerulonephritis (GN) remains poorly defined. We investigated the association between OBPM and renal histopathological lesions, focusing on arteriolosclerosis, and assessed their prognostic significance. This retrospective longitudinal study included 66 adults with biopsy-proven GN. All patients underwent standardized OBPM, laboratory evaluation, and renal biopsy. Histopathological assessment included glomerular, vascular, tubular, and interstitial lesions. Patients were followed for 36 months. Mixed-effects models evaluated longitudinal changes in blood pressure, proteinuria, and estimated glomerular filtration rate (eGFR), while logistic regression identified predictors of renal and cardiovascular outcomes. Patients with arteriolosclerosis had significantly higher systolic blood pressure (SBP) than those without (130 vs. 120 mmHg, p = 0.032). SBP > 130 mmHg was associated with arteriolosclerosis (p = 0.004), arterial intimal fibrosis (p = 0.005), crescentic lesions (p = 0.033), and glomerulosclerotic changes (p = 0.048), whereas no associations were observed for diastolic blood pressure (DBP). During follow-up, proteinuria significantly decreased (p < 0.001), whereas SBP remained stable. Arteriolosclerosis was associated with a steeper decline in eGFR over time (interaction β = -4.91 mL/min/1.73 m

Indexed as

ArteriolosclerosisGlomerulonephritisHypertensionRenal Insufficiency, ChronicAdultBiopsyBlood PressureBlood Pressure DeterminationBlood Pressure Monitoring, AmbulatoryDisease ProgressionFemaleGlomerular Filtration RateHumansKidneyLongitudinal StudiesMaleblood pressurekidney diseaseproteinuriarenal biopsyrenal function

Identifiers

PMID42762084
PMCPMC13589304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.