ReviewThe Journal of clinical and aesthetic dermatology2026
Clinical Applications of Vitamin C in Dermatology: A Systematic Review.
Review in The Journal of clinical and aesthetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate clinical applications, efficacy profiles, and delivery strategies of vitamin C and its derivatives in dermatology.
methodsA systematic review of PubMed and Scopus identified studies published from 2020 onward, evaluating topical, injectable, or systemic vitamin C formulations. Of 263 screened publications, 44 met inclusion criteria. Data were extracted regarding derivative type, delivery platform, and outcomes.
resultsAscorbic acid remains the most clinically validated formulation, with low-pH stabilized systems and L-ascorbic acid, vitamin E, and ferulic acid-type complexes consistently improving photoaging, structural aging, pigmentary disorders, and periprocedural healing. Ascorbyl tetraisopalmitate shows superior lipophilic stability, benefiting pigmentary and structural aging. Tetrahexyldecyl ascorbate is preferred for sensitive skin but requires acetyl zingerone stabilization. Ascorbyl glucoside with or without arginine is well tolerated for chronic hyperpigmentation. Sodium ascorbyl phosphate improves texture and pigmentation, particularly when paired with microneedling. Bis-glyceryl ascorbate demonstrates niche utility for preventing tyrosine kinase inhibitor-associated hand-foot skin reaction. Ascorbyl palmitate and magnesium ascorbyl phosphate emulgels provide rapid pigment lightening. Across modalities, procedural delivery-microneedling, jet injection, and radiofrequency-assisted laser import-enhances penetration and clinical response. Dietary vitamin C at 40 to 80 mg per day offers modest systemic photoprotection, hydration, and wrinkle-smoothing benefits, even without overt deficiency. LIMITATIONS: Study heterogeneity and a paucity of standardized data, particularly regarding diverse phototypes, restrict direct comparison; further research is required to guide optimal dermatologic use.
conclusionClinical effectiveness of vitamin C depends on derivative chemistry, vehicle, pH, stabilization strategy, and delivery method. Personalized selection by skin type, treatment goals, and delivery modality is essential.
Indexed as
Identifiers
42761976PMC13588479What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.