Evidence map›Paper›PMID 42761940›Full record

ReviewMethodist DeBakey cardiovascular journal2026

Hypertrophic Cardiomyopathy is a Disease of Sarcomere Proteins.

A J Marian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methodist DeBakey cardiovascular journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

A J MarianCenter for Cardiovascular Genetics, Institute of Molecular Medicine, Department of Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, US.ORCID https://orcid.org/0000-0002-1252-7120

Funding

Pathogenic Role of Selected Cardiac Myocyte- and Fibroblast-Specific Epigenetic Changes in LaminopathiesR01HL132401 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Ali J Marian · 2016 to 2026
$6.0M
Cytosolic DNA is the Link Between Genomic Instability and Cardiovascular AgingR01AG082751 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Ali J Marian · 2023 to 2026
$2.4M
Cell type-Specific Therapeutic Targeting of canonical WNT Pathway in Arrhythmogenic CardiomyopathyR01HL151737 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MARIAN, ALI J · 2020 to 2023
$2.0M
NHLBI NIH HHS R01 HL132401NHLBI NIH HHS R01 HL151737NIA NIH HHS R01 AG082751
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is a primary disease of cardiac myocytes caused by mutations in genes encoding sarcomere proteins. The ensuing phenotype, however, is multicellular, induced by biological and functional changes in myocytes and non-myocyte cardiac cells, particularly fibroblasts. The molecular genetic basis of HCM has been partially elucidated, and over three dozen genes are implicated as causes of HCM.

Indexed as

Cardiomyopathy, HypertrophicCarrier ProteinsMutationSarcomeresAnimalsCardiac MyosinsGenetic Predisposition to DiseaseHumansMyosin Binding Protein CMyosin Heavy ChainsPhenotypeCardiac MyosinsCarrier ProteinsMYH7 protein, humanMyosin Binding Protein CMyosin Heavy Chainscardiomyopathygeneticsheart failuremutationssarcomere

Identifiers

PMID42761940
PMCPMC13588226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.