ArticleInternational journal of chronic obstructive pulmonary disease2026
Screening Utility of Lower Limb Muscle Ultrasound for Sarcopenia in COPD Patients.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Sarcopenia is a common but underdiagnosed extrapulmonary complication in patients with chronic obstructive pulmonary disease (COPD) and contributes to poor clinical outcomes. This study aimed to investigate the screening utility of rectus femoris cross-sectional area (RFCSA), femoral muscle thickness (FMT), and quadriceps femoris muscle thickness (QFMT) for sarcopenia in COPD patients. Patients and Methods: This single-center cross-sectional study enrolled 61 COPD patients. According to the sarcopenia criteria, patients were classified into sarcopenia group (n=24) and non-sarcopenia group (n=37). All participants underwent pulmonary function tests, grip strength measurement, 6-meter walk test, 5-repetition sit-to-stand test, and bioelectrical impedance analysis. QFMT, FMT, and RFCSA were measured by a single experienced sonographer using a standardized protocol. Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were performed. Results: The proportion of participants with sarcopenia in this COPD cohort was 39.34% (24/61). All ultrasound parameters were significantly reduced in the sarcopenia group: QFMT (2.28 cm vs 2.57 cm, p<0.001), FMT (1.30±0.21 cm vs 1.43±0.23 cm, p=0.033), and RFCSA (4.25±0.75 cm Conclusion: Lower limb muscle ultrasound parameters, particularly QFMT, are significantly reduced in COPD patients with sarcopenia. Ultrasound appears promising as a screening tool but requires validation in larger, prospective, multicenter studies.
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