Evidence map›Paper›PMID 42761829›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Plasma levels and peripheral DNA methylation of IGF-1 and IGF-2 across knee osteoarthritis pain phenotypes in middle-aged and older adults.

Muhammad Abbas, Javier A Tamargo, Yutao Zhang, Carlos J Cruz, John Gilliam, Stephanie Wohlgemuth, Kevin Wu, Roland Staud, Li Chen, Burel R Goodin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muhammad AbbasDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.
Javier A TamargoDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.
Yutao ZhangDepartment of Biostatistics, University of Florida, Gainesville, Florida, USA.
Carlos J CruzDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.
John GilliamDepartment of Applied Physiology and Kinesiology, Laboratory for Rehabilitation Neuroscience, University of Florida, Gainesville, FL, USA.
Stephanie WohlgemuthDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Kevin WuDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Roland StaudDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Li ChenDepartment of Biostatistics, University of Florida, Gainesville, Florida, USA.
Burel R GoodinDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Roger B FillingimDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.
Christiaan LeeuwenburghDepartment of Medicine, Division of Geriatric Medicine, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USA.
Yenisel Cruz-AlmeidaDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.

Funding

Ethnic Differences in Responses to Painful StimuliR37AG033906 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2014 to 2023
$12.9M
Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain TissueR01AG067757 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2020 to 2024
$4.2M
the Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) ProgramT32AG049673 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2015 to 2024
$3.2M
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
University of Florida Partnerships Across Interdisciplinary Networks: Training through Engineering, epidemiology & Addiction Medicine (UF PAIN TEAM)T90AR085527 · NIAMS · UNIVERSITY OF FLORIDA · PI Kyle D Allen, Yenisel Cruz-Almeida · 2024 to 2026
$1.0M
University of Florida Partnerships Across Interdisciplinary Networks: Training through Engineering, epidemiology & Addiction Medicine (UF PAIN TEAM)R90AR085802 · NIAMS · UNIVERSITY OF FLORIDA · PI Kyle D Allen, Yenisel Cruz-Almeida · 2024 to 2026
$1.0M
NIAMS NIH HHS R90 AR085802NIAMS NIH HHS T90 AR085527NIA NIH HHS L32 AG096730NIA NIH HHS R01 AG059809NIA NIH HHS R01 AG067757NIA NIH HHS R37 AG033906NIA NIH HHS T32 AG049673
6 · The paper itself

Abstract

Osteoarthritis (OA) is a leading cause of pain and disability, yet the biological mechanisms linking structural disease and pain remain incompletely understood. Insulin-like growth factors (IGFs) are involved in cartilage homeostasis, inflammation, and pain signaling and may serve as biomarkers or therapeutic targets in OA. This exploratory cross-sectional study examined associations between circulating levels and peripheral blood DNA methylation of

Indexed as

EpigeneticsInsulin growth factorsOlder adultsOsteoarthritisPainPlasma protein

Identifiers

PMID42761829
PMCPMC13587716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.