Evidence map›Paper›PMID 42761712›Full record

ArticleInternational journal of ophthalmology2026

Angiogenesis-RNA modification in diabetic retinopathy: biomarkers and targets.

Xue Wang, Dan-Ping Wu, Wei Du, Rui Li, Wei Lou, Ran-Ran Chen, Yu-Jie Liao, Qian Li, Xiao-Mei Li, Hong-Ping Cui and 1 more

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Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xue WangDepartment of Ophthalmology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Dan-Ping WuDepartment of Ophthalmology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Wei DuDepartment of Ophthalmology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Rui LiDepartment of Ophthalmology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Wei LouDepartment of Ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Ran-Ran ChenDepartment of Ophthalmology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Yu-Jie LiaoDepartment of Ophthalmology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Qian LiDepartment of Ophthalmology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Xiao-Mei LiDepartment of Ophthalmology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Hong-Ping CuiDepartment of Ophthalmology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Jin-Ling ZhangDepartment of Ophthalmology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify biomarkers and potential therapeutic targets related to angiogenesis and RNA modification in diabetic retinopathy (DR).

methodsThe Gene Expression Omnibus (GEO) datasets GSE12610, GSE87433, and GSE111465, which contain retinal samples from diabetic and normal mice, were analyzed to identify differentially expressed genes (DEGs). The DEGs were then intersected with angiogenesis- and RNA modification-related genes (A&RMRGs) obtained from GeneCards and other databases to identify differentially expressed A&RMRGs in DR. Hub genes were subsequently identified from the protein-protein interaction (PPI) network built on the enrichment results. Their diagnostic value was then estimated by receiver operating characteristic (ROC) analysis, and their expression levels were tested for associations with immune cell infiltration. Regulatory networks of hub genes were constructed using MicroRNA Target Prediction Database (miRDB), ChIPBase, and the Comparative Toxicogenomics Database (CTD). To validate the bioinformatic findings, hub gene transcript levels were quantified with reverse transcription quantitative polymerase chain reaction (RT-qPCR) in high-glucose-treated rat retinal microvascular endothelial cells (rRMECs).

resultsForty-two A&RMRGs showed differential expression in the diabetic retina, with Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment implicating RNA modification and immune-inflammatory regulation, alongside Gene Set Enrichment Analysis (GSEA) evidence of activated RNA-silencing and fatty-acid-transport programs and suppressed neuronal and retinoid-cycle programs. Seven hub genes (

conclusionThese findings identify

Indexed as

angiogenesisbiomarkersdiabetic retinopathyRNA modificationtherapeutic targets

Identifiers

PMID42761712
PMCPMC13586933

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