ArticleInternational journal of ophthalmology2026
Layer and zone-specific study of corneal optical density in dry eye disease: links to tear film metrics.
Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo assess the differences in corneal optical density (COD) between young patients with dry eye and healthy controls, as well as to evaluate the correlations with tear film parameters.
methodsThis cross-sectional study involved 30 patients with dry eye and 60 age-matched controls (aged 18-35y). All participants underwent a thorough ophthalmic evaluation, including visual acuity testing, refraction, the Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), the Schirmer's test, corneal staining, and Pentacam densitometry.
resultsThe groups were matched for age (21.93±2.88y
conclusionYoung patients with dry eye exhibit increased COD, especially in the anterior and middle corneal layers, which correlates with symptom severity. These results imply that corneal densitometry could act as an objective measure of dry eye severity, supplementing traditional clinical evaluations.
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