Evidence map›Paper›PMID 42761600›Full record

ArticleMaterials today. Bio2026

Hepatic fibrosis extracellular matrix stiffness induces abnormal maturation of dendritic cell via AMPK inhibition-mediated cholesterol accumulation.

Xianlin Zeng, Pan Luo, Cuifang Wu, Jinhua Long, Shuai Zhang, Yun Wang, Lijing Teng, Honghong Zhang, Deqiao Fan, Zuquan Hu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xianlin ZengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Pan LuoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Cuifang WuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Jinhua LongDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, PR China.
Shuai ZhangDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, PR China.
Yun WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Lijing TengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Honghong ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Deqiao FanState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Zuquan HuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Pu XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.
Zhu ZengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Basic Medical Sciences/School of Biology & Engineering, Guizhou Medical University, Guiyang, 561113, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cell (DC)-based immunotherapy shows limited efficacy against hepatic fibrosis, and the underlying mechanometabolic crosstalk remains unclear. Here, from a mechanobiological perspective, we demonstrate that increased extracellular matrix (ECM) stiffness in the fibrotic liver triggeres antigen-independent abnormal DC maturation, characterized by elevated co-stimulatory molecules, impaired phagocytic capacity, reduced IL-10 secretion, and suppressed regulatory T cell (T

Indexed as

AMP-activated protein kinaseCholesterol metabolismDendritic cellsExtracellular matrix stiffnessHepatic fibrosis

Identifiers

PMID42761600
PMCPMC13586880

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.