ArticleMethodsX2026
Protocol paper: Evaluating the effect of isometric handgrip exercise on cognitive fatigue while solving logical reasoning questions.
Article in MethodsX, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prolonged logical reasoning induces cognitive fatigue, impairing the processing speed and accuracy. Building on our prior findings that acute isometric handgrip exercise (IHE) enhances working memory and speed, this trial aimed to evaluate whether concurrent, intermittent IHE mitigates cognitive fatigue and preserves capacity during logical reasoning. Methods: In this two-arm, parallel-group trial, 100 healthy right-handed medical students (1st and 2nd year, aged 18-25 years) will be randomly allocated (1:1) to the exercise (EXE) or control (CON) group.While completing the logical reasoning questionnaire using Raven's Standard Progressive Matrices with their dominant right hand, EXE participants will perform left-hand intermittent IHE (18-s squeeze at ∼3/10 of Rating of Perceived Exertion, 30-s rest), whereas CON participants will hold the ball without squeezing it.For both groups, at baseline and immediately post-task, attention (Flanker Inhibitory Control and Attention Test) and processing speed (Speeded Matching Test) will be assessed using the NIH Toolbox®V3 software, alongside subjective cognitive fatigue using the Multidimensional Fatigue Inventory (MIF-20). The logical reasoning performance (total score on Raven's Progressive Matrices) will also be compared between groups. Validation: Combining standardized neurocognitive and psychometric assessments with a motor-cognitive protocol provides a validated framework for evaluating acute physical interventions for cognitive fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.