ArticleOpen forum infectious diseases2026
Evaluation of Changes in
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Daptomycin and linezolid may have more favorable safety and efficacy profiles compared to vancomycin and require less therapeutic monitoring. To capitalize on these advantages, the University of Colorado Hospital relaxed prescribing restrictions and updated local guidance for the treatment of Gram-positive infections, resulting in increased daptomycin and linezolid utilization. The objective of this study was to assess the impact of liberalized daptomycin and linezolid use on minimum inhibitory concentrations (MICs) in Gram-positive organisms. Methods: This retrospective, single-center study included all Results: Minimum inhibitory concentrations from 19 160 isolates were evaluated, of which 7224 were HA. Linezolid use increased to 43.7 days of therapy per 1000 patient days (DOT/1000PD), and daptomycin use increased to 15.7 DOT/1000PD post-implementation. Linezolid GM MICs trended downward pre-implementation, and the trajectory was unaffected by implementation except in coagulase-negative Conclusions: The liberalization of daptomycin and linezolid did not result in clinically relevant increases in resistance. Further studies are needed to confirm the durability of these results, specifically among CoNS and VRE.
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