Evidence map›Paper›PMID 42761548›Full record

ArticleJournal of the Endocrine Society2026

Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution.

Timofey Glinin, Sergey Isaev, Anastasia Shubina, Igor Adameyko, Elham Khanafshar, Julie A Sosa, James Koh

Abstract read
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In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Timofey GlininLaboratory of Endocrine Neoplasia, Department of Surgery, University of California at SanFrancisco, San Francisco, CA 94143, USA.ORCID https://orcid.org/0000-0003-0550-741X
Sergey IsaevDepartment of Neuroimmunology, Center for Brain Research, Medical University Vienna, Vienna 1090, Austria.
Anastasia ShubinaOpen Longevity, Los Angeles, CA 91403,USA.
Igor AdameykoDepartment of Neuroimmunology, Center for Brain Research, Medical University Vienna, Vienna 1090, Austria.ORCID https://orcid.org/0000-0001-5471-0356
Elham KhanafsharDepartment of Pathology, University of California at SanFrancisco, San Francisco, CA 94143, USA.
Julie A SosaLaboratory of Endocrine Neoplasia, Department of Surgery, University of California at SanFrancisco, San Francisco, CA 94143, USA.
James KohLaboratory of Endocrine Neoplasia, Department of Surgery, University of California at SanFrancisco, San Francisco, CA 94143, USA.ORCID https://orcid.org/0000-0001-6853-8606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary hyperparathyroidism (PHPT) is a common endocrine neoplastic disorder caused by excessive parathyroid hormone (PTH) secretion, predominantly due to single gland adenomas that arise in 1 of the 4 parathyroid glands. In the presence of a dominant hypersecretory adenoma, the remaining normal glands become functionally suppressed with attenuated PTH output. The mechanisms underlying suppression remain poorly understood. We performed single-nucleus RNA sequencing combined with immunofluorescence analysis to compare normal and suppressed human parathyroid glands. Transcriptomic analysis of 1.7 billion reads from 83 693 nuclei revealed 4 distinct parathyroid cell populations, including a PDE10A

Indexed as

hyperparathyroidismparathyroidprimary hyperparathyroidismsingle nuclei sequencing

Identifiers

PMID42761548
PMCPMC13586761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.