ArticleFrontiers in medicine2026
Early inflammatory and nutritional marker recovery patterns and short-term outcomes in critically ill older adults: a 72-h landmark cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Admission severity scores describe acute organ dysfunction but may not capture early recovery in older intensive care unit (ICU) patients. We examined whether investigator-defined changes in routinely measured inflammatory and nutritional markers during the first 72 h identified distinct recovery patterns associated with short-term outcomes. Methods: This single-center retrospective cohort included patients aged 65 years or older admitted from January 5, 2021, through May 31, 2026, who survived to a 72-h landmark and had first-window measurements at ICU admission (T0, 0-24 h) and 48-72 h (T1). Four rule-based recovery patterns were defined and assigned using internally derived marker thresholds and fixed directional/count rules finalized without reference to outcomes. The primary outcome was mortality from the landmark to day 28. Cox models sequentially adjusted for demographic factors, baseline clinical severity, and geriatric vulnerability. Within each bootstrap sample, pooled marker thresholds were re-estimated, patients were reassigned using the fixed operational rules, and the outcome models were refitted. Results: Among 934 screened admissions, 620 patients entered the landmark cohort and 122 died by day 28. Pattern 3 (initial extreme burden without improvement-rule fulfillment) included 180 patients and had the highest crude mortality (31.7%, 57/180), versus 9.8% (25/255) in Pattern 1. In the geriatric-adjusted model, the overall four-level association with mortality was not significant (likelihood-ratio Conclusion: Investigator-defined early marker recovery patterns described clinical heterogeneity but were not independently associated with 28-day mortality after geriatric adjustment and did not add predictive value. Exploratory overall associations with prolonged ventilation and ICU stay require external validation. Prospective evaluation is required before clinical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.