ArticleInternational journal of ophthalmology2026
One-year structural and functional outcomes of accelerated epithelium-off corneal cross-linking in keratoconus.
Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo evaluate the structural and functional outcomes of accelerated epithelium-off corneal collagen cross-linking (CXL) in patients with keratoconus (KC) 1y after treatment.
methodsThis retrospective study included patients who underwent an accelerated epi-off CXL for progressive KC at the Department of Ophthalmology, Sveti Duh University Hospital, Zagreb, Croatia, between January and December 2023. The protocol consisted of epithelial removal, riboflavin 0.1% instillation for 3min, and ultraviolet-A (UVA) irradiation at 9 mW/cm
resultsA total of 45 eyes from 45 patients (mean age: 29.1±6.2y) were included in the study. One year after CXL treatment, only Kmax front (55.20 to 55.00 D) showed a statistically significant decrease among the keratometric parameters. A statistically significant reduction was observed in all curvature-based indices, except for IHA, which did not reach statistical significance, whereas Rmin (6.11 to 6.14 mm) showed a statistically significant increase. Additionally, CCT, anterior radius of curvature (ARC), and best-corrected distance visual acuity (BCVA) also demonstrated statistically significant increase.
conclusionAccelerated epi-off CXL results in significant structural and functional improvements in KC at the 1-year follow-up. Decreased Kmax and curvature indices, increased Rmin, CCT, and ARC, and improved BCVA indicate better corneal regularity, biomechanical stability, and functional vision, with ABCD analysis confirming disease stabilization.
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