SynthesisFrontiers in fungal biology2026
Fungal detection, diagnostic approaches, and antifungal susceptibility in diabetic foot ulcers: a systematic review of recent evidence.
Synthesis in Frontiers in fungal biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Background: Fungal infections are an emerging but underrecognized concern in diabetic foot ulcers (DFU); and may contribute to delaying healing and complicate clinical outcomes. This study reviewed available evidence to identify the neglected contribution of fungi to DFUs and to explore their antifungal susceptibility patterns. Methods: A systematic search in PubMed, Web of Science, and Google Scholar databases for articles published from 2021 to 2025. Eligible articles were screened, extracted, and reported according to PRISMA guidance, and methodological quality was assessed using JBI tools. Results: Of the 1,030 publications identified, 26 studies comprising 3,851 patients met the inclusion criteria, all reporting fungal involvement in DFUs. Conclusions: These findings suggest a potentially important role of fungi in DFUs; however, evidence on antifungal susceptibility remains limited. Therefore, greater attention to fungal involvement is warranted to reduce infection burden, minimize complications, and improve health outcomes and quality of life in patients with diabetes. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261404556, identifier CRD420261404556.
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