Evidence map›Paper›PMID 42761272›Full record

ArticleFrontiers in immunology2026

Synthetic consensus DNA vaccines against Merkel cell polyomavirus large and small T antigens induce robust polyfunctional T cell responses.

Pratik S Bhojnagarwala, Elizabeth K Duperret, Aspen Trautz, David B Weiner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pratik S BhojnagarwalaVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States.
Elizabeth K DuperretVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States.
Aspen TrautzVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States.
David B WeinerVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States.

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
Targeting hyaluronan in the tumor microenvironment to improve DNA vaccine immunotherapyF32CA213795 · NCI · WISTAR INSTITUTE · PI DUPERRET, ELIZABETH KENNEDY · 2017 to 2018
$94k
NCI NIH HHS F32 CA213795NCI NIH HHS P30 CA010815
6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a high mortality rate and limited therapeutic options. Approximately 80% of MCC cases are associated with Merkel cell polyomavirus (MCPyV). The Large T antigen (LTAg) and Small T antigen (STAg) of MCPyV are persistently expressed in tumors and important for viral maintenance and oncogenic transformation of infected cells, making them attractive targets for therapeutic vaccination. Here, we describe the development and preclinical evaluation of DNA vaccines against MCPyV LTAg (LTAgvax) and STAg (STAgvax). Vaccines were designed based on highly conserved regions across MCPyV strains and demonstrated robust expression

Indexed as

Antigens, Viral, TumorCancer VaccinesCarcinoma, Merkel CellMerkel cell polyomavirusPolyomavirus InfectionsSkin NeoplasmsTumor Virus InfectionsVaccines, DNAAnimalsCD8-Positive T-LymphocytesFemaleHumansMiceMice, Inbred C57BLVaccines, SyntheticAntigens, Viral, TumorCancer VaccinesVaccines, DNAVaccines, SyntheticDNA vaccinationlarge T antigenMerkel cell carcinomaMerkel cell polyomavirus (MCPyV)small T antigen

Identifiers

PMID42761272
PMCPMC13585920

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.