Evidence map›Paper›PMID 42761222›Full record

ArticleFrontiers in bioinformatics2026

Alternative splicing remodeling and splicing factor regulatory networks define immune-associated molecular heterogeneity in dilated cardiomyopathy.

Jia Li, Yiyu He, Xianxian Zhao, Zhifu Guo, Jinchao Song, Xiaowei Song

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Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia LiDepartment of Cardiovascular Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Yiyu HeDepartment of Anesthesiology, Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Shanghai, China.
Xianxian ZhaoDepartment of Cardiovascular Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhifu GuoDepartment of Cardiovascular Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Jinchao SongDepartment of Anesthesiology, Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Shanghai, China.
Xiaowei SongDepartment of Cardiovascular Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dilated cardiomyopathy (DCM), a progressive cardiac disorder marked by ventricular dilatation and systolic dysfunction, involves a complex interplay between genetic and immune dysregulation. However, how alternative splicing remodeling contributes to its molecular heterogeneity remains poorly understood. Here, we performed an integrated transcriptomic analysis to characterize DCM-associated alternative splicing landscapes and their regulation by splicing factor networks. We identified widespread differential alternative splicing (DAS) events in DCM, with affected genes significantly enriched in cardiac contraction, sarcomere organization, calcium handling, extracellular matrix remodeling, and protein metabolism. Representative splicing events in key cardiac genes, including

Indexed as

alternative splicingdilated cardiomyopathymachine learningmolecular heterogeneitysplicing factor

Identifiers

PMID42761222
PMCPMC13585734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.