ArticleCase reports in urology2026
Phosphodiesterase-5 Inhibitor Use Masking a Necrotizing Syphilitic Infection: A Rare Differential Diagnosis of Priapism.
Article in Case reports in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Acute penile enlargement is often presumed to indicate priapism, particularly after Phosphodiesterase-5 inhibitor use. However, alternative diagnoses, including infectious and necrotizing processes, should be considered-especially in patients with a history of unprotected sex-to avoid delayed or inappropriate management. Case Presentation: A 43-year-old male with a history of intravenous drug use presented with acute penile swelling and leukocytosis (20,500/ Conclusion: Acute penile enlargement following Phosphodiesterase-5 inhibitor use is not necessarily attributable to priapism and may instead be caused by infectious or necrotizing etiologies. Prompt recognition, initiation of antimicrobial therapy, and timely surgical intervention are critical to preserve penile tissue and erectile function.
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