ArticleMaterials today. Bio2026
Bioinspired liquid metal-spidroin (LMS) stripe microneedle actuators.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Intelligent wound dressings have demonstrated significant clinical value. Among which flexible actuators dressings hold promise for real-time monitoring and on-demand treatment adjustment. Herein, we develop a novel bioinspired liquid metal-spidroin (LMS) stripe microneedle (MN) actuators for multifunctional wound management. The LMS system consists of recombinant spider silk proteins (spidroin) matrices embedded with gallium-based liquid metal droplets and patterned into asymmetric microneedle stripes by casting and programmed cutting. Benefiting from selaginella-inspired layouts, LMS composites exhibit near-infrared-triggered bending and coiling, while morphology-encoded microchannels guide interstitial fluid along predefined routes without external pumps. The liquid metal core also functions as a deformable electrode and triboelectric nanogenerator, enabling energy harvesting and self-sensing during microneedle deformation. In vitro and in vivo experiments demonstrate that epidermal growth factor-loaded LMS microneedle bandages conformally wrap cutaneous defects and significantly accelerate wound closure and re-epithelialization compared with control dressings. Histological analysis reveals no evident systemic toxicity, indicating acceptable biosafety. These findings suggest that LMS stripe microneedle actuators provide a promising platform for next-generation intelligent wound dressings.
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