Evidence map›Paper›PMID 42761130›Full record

ArticleFrontiers in pediatrics2026

Risk factors associated with birth asphyxia at Pumwani Maternity Hospital, Nairobi, Kenya: a case-control study.

Ruth Wagathu, James Orwa, Peterson Kiraithe, Abednego Ongeso, Evah Maina, David Gerald Omondi, Benard Mutwiri, Timothy Guetterman

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ruth WagathuSchool of Nursing and Midwifery, Aga Khan University, Nairobi, Kenya.
James OrwaDepartment of Population Health, Aga Khan University, Nairobi, Kenya.
Peterson KiraitheSchool of Nursing and Midwifery, Aga Khan University, Nairobi, Kenya.
Abednego OngesoSchool of Nursing and Midwifery, Aga Khan University, Nairobi, Kenya.
Evah MainaSchool of Pharmacy and Health Sciences, United States International University, Nairobi, Kenya.
David Gerald OmondiSchool of Nursing and Midwifery, Aga Khan University, Nairobi, Kenya.
Benard MutwiriSchool of Nursing and Midwifery, Aga Khan University, Nairobi, Kenya.
Timothy GuettermanDepartment of Family Medicine, University of Michigan, Ann Arbor, MI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Birth asphyxia remains a leading cause of neonatal mortality and morbidity in low- and middle-income countries. In Kenya, it accounts for approximately 29% of neonatal deaths despite the implementation of national newborn care guidelines. This study investigated the risk factors associated with birth asphyxia at Pumwani Maternity Hospital, Nairobi, Kenya. Methods: A matched case-control study was conducted at Pumwani Maternity Hospital, Nairobi, Kenya, between February and September 2024. Cases were newborns with a five-minute APGAR score <7, while controls had a five-minute APGAR score ≥7. A total of 540 newborns (270 cases and 270 controls) were consecutively recruited. Data were collected using a researcher-administered questionnaire and a data abstraction tool. Univariable and multivariable conditional logistic regression analyses were performed to identify factors associated with birth asphyxia. All analyses were conducted using R version 4.5.1 (2025-06-13 ucrt), and statistical significance was set at Results: Most mothers were aged above 20 years (80.2%), married or cohabiting (75.6%), unemployed (61.9%), and had attained secondary level education (58.0%). Complications during labour were strongly associated with birth asphyxia (AOR: 24.26; 95% CI: 7.65-76.95). Additionally, previous adverse obstetric history (AOR: 2.18; 95% CI: 1.14-4.17), maternal medical and obstetric conditions during pregnancy (AOR: 1.82; 95% CI: 1.04-3.19), and non-cephalic fetal presentation (AOR: 8.92; 95% CI: 1.77-45.00) were also independently associated with higher odds of birth asphyxia. Conversely, spontaneous onset of labour (AOR: 0.20; 95% CI: 0.05-0.76), spontaneous vaginal delivery (AOR: 0.02; 95% CI: 0.00-0.10), and delivery conducted by trained healthcare providers were associated with reduced odds of birth asphyxia. Conclusion: Birth asphyxia was strongly associated with several maternal and obstetric factors. Strengthening antenatal risk identification, timely management of labour complications, skilled intrapartum care, and early recognition of high-risk deliveries may reduce the burden of birth asphyxia and improve neonatal outcomes in similar low-resource settings.

Indexed as

birth asphyxiacase-control studyfetal hypoxiaKenyanewbornrisk factors

Identifiers

PMID42761130
PMCPMC13585704

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