ArticleFrontiers in microbiology2026
Proteomic remodeling of outer membrane vesicles in antibiotic-resistant
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antibiotic resistance in Methods: Metronidazole and levofloxacin-resistant derivatives of the Results: Comparative proteomic analysis revealed remodeling of both cellular and OMV-associated protein profiles following acquisition of antibiotic resistance. While 236 proteins were shared among all strains, distinct resistance-associated protein signatures were identified in the levofloxacin- and metronidazole-resistant derivatives. Functional enrichment highlighted pathways associated with membrane transport, oxidative stress response, metabolic adaptation, and cellular envelope organization. OMV proteomes differed from their corresponding whole-cell proteomes, a pattern consistent with, though not proof of, selective protein packaging. Conserved vesicle-associated proteins, including UreA, UreB, GroEL, and GroES, were detected in OMVs from all strains, whereas OMVs from the levofloxacin-resistant derivative contained proteins associated with redox homeostasis and iron metabolism, including SelA and FeoB. In addition, differential representation of the virulence factors CagA and VacA was observed between susceptible and resistant OMVs. Conclusion: Acquisition of antibiotic resistance in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.