ArticleFrontiers in medicine2026
Case Report: Autoimmune hepatitis following oxaliplatin exposure presenting with multifactorial non-cirrhotic portal hypertension and recurrent parastomal variceal bleeding.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ectopic variceal hemorrhage accounts for approximately 5% of all variceal bleeding episodes and represents an uncommon manifestation of portal hypertension. This report describes recurrent parastomal variceal bleeding in a 43-year-old woman with rectal adenocarcinoma who underwent abdominoperineal resection followed by five cycles of oxaliplatin-containing chemotherapy. During chemotherapy, severe hepatocellular injury developed. A liver biopsy performed in June 2020 demonstrated severe interface hepatitis with lymphoplasmacytic portal inflammation, findings that supported a diagnosis of autoimmune hepatitis (AIH). No histopathological features diagnostic of portosinusoidal vascular disease (PSVD) were identified. Subsequently, progressive splenomegaly, gastroesophageal and parastomal varices, and a directly measured portal pressure of 35 cm H
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