Evidence map›Paper›PMID 42761100›Full record

ArticleFrontiers in cell and developmental biology2026

Defining the critical axial length threshold for transition from physiological growth to pathological fundus structural remodeling in adolescent myopia.

Ting Zhou, Xu Zhang, Yajie Zheng, Jie Wang, Yu Jiang, Hanyang Yu, Shitong Huang, Ningfeng Li, Xinrui Zou, Shukui Li and 12 more

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In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

22 authors.

Ting Zhou *Department of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Xu Zhang *Department of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Yajie Zheng *EVision Technology (Beijing) Co., Ltd., Beijing, China.
Jie Wang *EVision Technology (Beijing) Co., Ltd., Beijing, China.
Yu JiangDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Hanyang YuDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Shitong HuangDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Ningfeng LiDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Xinrui ZouDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Shukui LiDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Weihao BiDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Shuoxian ChenDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Siyu LiuDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Zhimeng ZhangDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Feng ShiDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Wenzhi HuangDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Danna ChenDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Hanyue YangQiqihar Medical University, Qiqihar, Heilongjiang, China.
Xi WangEVision Technology (Beijing) Co., Ltd., Beijing, China.
Zongyin GaoDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.
Xingye WangEVision Technology (Beijing) Co., Ltd., Beijing, China.
Yunxia LengDepartment of Ophthalmology, The Second Affiliated Hospital, South China University of Technology, Guangzhou First People's Hospital, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dynamic evolution of fundus tessellation density (FTD) and peripapillary atrophy (PPA) during childhood myopia progression-and their threshold-associated transitions relative to axial length (AL)-remain incompletely characterized. To address this gap, we prospectively quantified longitudinal FTD and PPA changes in a school-aged cohort with progressive myopia, and modeled their nonlinear dose-response relationships with AL to identify the biomechanical threshold at which fundus remodeling shifts from physiological adaptation to early pathological tissue deformation. A cohort of 371 children aged 8-11 years was prospectively followed for 2 years. FTD and PPA were measured via a validated deep learning system; myopia progression subtypes were stratified via k-means clustering by annual AL elongation rate; longitudinal trajectories and inflection points were estimated via linear mixed-effects models and quadratic regression. Three progression phenotypes emerged: stable (0.147 mm/y), moderate (0.443 mm/y), and rapid (0.827 mm/y). Each 1 mm AL increase correlated with 0.127 mm

Indexed as

axial elongationchildhood myopiaChoroid–sclera biomechanicsfundus tessellation densitypathological transition thresholdperipapillary atrophyposterior pole remodellingquantitative fundus imaging

Identifiers

PMID42761100
PMCPMC13585632

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.