ArticleFrontiers in immunology2026
Elucidating molecular mechanisms of allergic sensitization to olive pollen through transcriptomics.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Olive pollen allergy, a leading cause of seasonal allergic rhinitis and asthma in Mediterranean regions, is becoming increasingly relevant worldwide due to the expansion of olive cultivation. Despite its significant public health impact, the molecular mechanisms underlying sensitization to olive pollen remain poorly understood. Methods: In this study, RNA sequencing was used to perform transcriptomic profiling on Results: A total of 37 differentially expressed genes (DEGs) were found exclusively in the patient group. Validation by RT-qPCR in an independent cohort confirmed the expression patterns of selected DEGs. Functional enrichment analyses associated these DEGs with immune pathways, ossification processes, and cytokine activity. Notably, upregulated genes such as Conclusion: Overall, this study provides new insights into the transcriptomic landscape of olive pollen allergy, identifying candidate biomarkers and biological pathways with translational relevance for improving diagnosis and advancing personalized treatment strategies in allergic diseases.
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