Evidence map›Paper›PMID 42761051›Full record

ArticleFrontiers in medicine2026

Disseminated intravascular coagulation as a prognostic factor in heatstroke: a retrospective cohort study based on Japanese insurance claims.

Hiroyuki Koami, Yutaro Furukawa, Hiroki Ushijima, Daisuke Muroya, Tadashi Matsuoka, Takaaki Totoki, Kenji Kandori, Takahiro Oishi, Kasumi Satoh, Yutaka Umemura and 4 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Hiroyuki KoamiDepartment of Emergency and Critical Care Medicine, Saga University, Saga, Japan.
Yutaro FurukawaDepartment of Emergency and Critical Care Medicine, Saga University, Saga, Japan.
Hiroki UshijimaDepartment of Emergency and Critical Care Medicine, Saga University, Saga, Japan.
Daisuke MuroyaLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Tadashi MatsuokaLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Takaaki TotokiLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Kenji KandoriLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Takahiro OishiLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Kasumi SatohDepartment of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Yutaka UmemuraLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Kazuma YamakawaLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Mineji HayakawaLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Kohji OkamotoLOCOMOCO (Landmark of Clinical Observations in MicrOcirculation and Coagulation Outcomes) Study Group, Tokyo, Japan.
Yuichiro SakamotoDepartment of Emergency and Critical Care Medicine, Saga University, Saga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Heatstroke is an emerging global health concern, particularly among the elderly. Disseminated intravascular coagulation (DIC) complicates about 20% of these cases and contributes to poor outcomes. The JAAM-2 DIC score, which excludes SIRS, has been validated in sepsis. However, its utility in heatstroke, a condition sharing pathophysiological features with sepsis, remains unexamined. To evaluate the association between heatstroke-associated DIC, defined by JAAM-2 criteria, and clinical outcomes, using a nationwide Japanese database of medical claims. Methods: We conducted a retrospective analysis using data from Japanese health insurance claims from 2014 to 2023. Among 2,633 adult patients admitted with heatstroke, 606 cases with complete DIC data on admission were included. Patients were categorized into DIC ( Results: The DIC group was older and exhibited higher rates of impaired consciousness, hepatic and renal dysfunction, bleeding/thrombotic complications, and mortality. Kaplan-Meier analysis showed significantly lower 28-day survival in the DIC group (log-rank Conclusion: JAAM-2 DIC is associated with poor clinical outcomes in patients with heatstroke, supporting the clinical importance of recognizing coagulopathy in this population.

Indexed as

disseminated intravascular coagulationheatstrokeJAAM-2 DIC criteriamortalitymultiple organ failurenationwide database

Identifiers

PMID42761051
PMCPMC13585736

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