ArticleFrontiers in pharmacology2026
Median effective dose and 95% effective dose of oliceridine combined with ciprofol for painless gastroscopy: a dose-finding study based on Dixon's up-and-down method.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To determine the median effective dose and estimate 95% effective dose of oliceridine combined with ciprofol for suppressing gastroscope insertion responses, stratified by sex. Methods: This prospective, sex-stratified trial enrolled patients between 16 January and 31 March 2026, at the General Hospital of Northern Theater Command. Patients, stratified into separate male and female cohorts, received an individualized dose of oliceridine followed by a fixed dose of ciprofol (0.4 mg/kg) for anesthesia induction. The oliceridine dose was determined using a modified Dixon up-and-down method, with an initial dose of 0.02 mg/kg. Subsequent doses increased or decreased by a ratio of 1.0:1.1 based on positive or negative responses. The positive response was defined as retching, coughing, body movement, or a greater than 30% increase in mean arterial pressure or heart rate within 1 min of insertion. The trial terminated upon reaching seven consecutive response reversals in each cohort. Results: A total of 29 male and 32 female patients completed the study. The ED Conclusion: For day-case painless gastroscopy, the ED
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