Evidence map›Paper›PMID 42760814›Full record

ReviewCancer medicine2026

Schwann Cells in Physical Nerve Injury and Tumor Perineural Invasion: A Functional Overview and Comparison.

Yanni Zheng, Xin Chen, Jiachen Liu, Jiayi Chen, Lei Tang, Wenjun Liu, Yuxin Lin, Xuedong Wei

Abstract readReview
In one paragraph

Review in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanni ZhengSuzhou Medical College, Soochow University, Suzhou, People's Republic of China.
Xin ChenSuzhou Medical College, Soochow University, Suzhou, People's Republic of China.ORCID https://orcid.org/0000-0001-8110-0000
Jiachen LiuSuzhou Medical College, Soochow University, Suzhou, People's Republic of China.ORCID https://orcid.org/0009-0002-8201-247X
Jiayi ChenSuzhou Medical College, Soochow University, Suzhou, People's Republic of China.
Lei TangDepartment of Urology, The Fourth Affiliated Hospital of Soochow University, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, People's Republic of China.
Wenjun LiuJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
Yuxin LinSuzhou Medical College, Soochow University, Suzhou, People's Republic of China.ORCID https://orcid.org/0000-0001-6543-0317
Xuedong WeiSuzhou Medical College, Soochow University, Suzhou, People's Republic of China.ORCID https://orcid.org/0000-0003-2000-2620

Funding

General Program of Jiangsu Health Commission H2019040Gusu Health Personnel Training Project of Suzhou City GSWS2019033The 26th Batch of Soochow University Undergraduate Extracurricular Academic Research Fund Project KY2024007Z
6 · The paper itself

Abstract

The nervous system exhibits remarkable stability, making its repair challenging. Compared to the central nervous system, peripheral nerve injuries demonstrate a greater potential for regeneration. Schwann cells, the unique myelinating glial cells of the peripheral nervous system, possess striking plasticity and support nerve regeneration through phenotypic transformation following injury. While Schwann cells are essential for nerve regeneration after injury, in the context of tumors, their reparative function is exploited to facilitate perineural invasion and the progression of cancer. However, the tumor-promoting effect of Schwann cells is context-dependent, and emerging evidence suggests that under specific conditions, Schwann cells may exert tumor-suppressive functions. This article aims to explore the complex roles of Schwann cells in both physical nerve injury and tumor-induced nerve damage, comparing their similarities and differences and seeking to provide insights for future research and potential therapeutic interventions.

Indexed as

Peripheral Nerve InjuriesSchwann CellsAnimalsHumansNeoplasm InvasivenessNerve Regenerationcancer progressionnerve injuryperipheral nervous systemSchwann cellstumor perineural invasion

Identifiers

PMID42760814
PMCPMC13589190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.