Evidence map›Paper›PMID 42760514›Full record

ArticleBMC psychiatry2026

The mediating role of brain structural-functional connectivity coupling in linking paternal education to BMI and depressive scores in young adults.

Yuhui Wang, Cancan Lin, Wenjie Xia, Xiao Zhang, Shutang Zhao, Tiefeng Ji, Xubo Wang, Defu Zhang, Yue Wang, Yuxin Du and 2 more

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In one paragraph

Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yuhui Wang *School of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Cancan Lin *School of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Wenjie XiaSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Xiao ZhangNHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing, China.
Shutang ZhaoSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Tiefeng JiSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Xubo WangDepartment of Psychiatry, Shandong Daizhuang Hospital, Shandong, China.
Defu ZhangSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Yue WangSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Yuxin DuSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China.
Hao YuSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China. yuhao@mail.jnmc.edu.cn.ORCID http://orcid.org/0000-0002-9785-8489
Shanling JiSchool of Mental Health, Jining Medical University, Jining, Shandong, 272056, China. jishanling@mail.jnmc.edu.cn.ORCID http://orcid.org/0000-0001-9521-1633

Funding

Beijing High-Level Innovation and Entrepreneurship Talent Support Program G202532215National Key Technology R&D Program of China 2023YFC2506204Natural Science Foundation of Shandong Province ZR2024QH652
6 · The paper itself

Abstract

backgroundParental education is associated with body mass index (BMI), mental health, and neurodevelopment in young adults, yet the neurobiological mechanisms remain unclear. This study investigated whether parental education is related to BMI and depressive scores through brain structural-functional connectivity (SC-FC) coupling.

methodsThis study included 490 healthy young adults who underwent resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) scans. Parental education was measured as years of schooling, BMI by weight/height

resultsPaternal education was significantly correlated with BMI (r = 0.10, P < 0.05) and depressive scores (r = -0.09, P < 0.05). Additionally, paternal education, BMI, and depressive scores were positively associated with SC-FC coupling in the right inferior parietal lobule (IPL, r = 0.19, corrected P < 0.001; r = 0.12, corrected P < 0.05; r = 0.10, corrected P < 0.05, respectively). Mediation analysis showed that the right IPL statistically mediated the associations of paternal education with both BMI (indirect effect = 0.01, 95% confidence interval (CI): 0.001-0.04) and depressive scores (indirect effect = 0.01, 95% CI: 0.001-0.03).

conclusionIn this cross-sectional study, paternal education was associated with BMI and depressive scores, with SC-FC coupling in the right IPL statistically mediating these associations. No corresponding effects were observed for maternal education. These findings suggest a potential neural pathway linking socioeconomic factors to physical and mental health outcomes. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Body Mass IndexBrainDepressionEducational StatusFathersAdultDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleYoung AdultBody mass indexDepressive scoresInferior parietal lobuleParental educationStructural-functional connectivity coupling

Identifiers

PMID42760514
PMCPMC13587411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.