ArticleThe AAPS journal2026
Area Under the Curve-Guided Therapeutic Drug Monitoring of Mycophenolic Acid in Lung Transplant Recipients: Volumetric Absorptive Microsampling and Population Pharmacokinetic-Based Limited Sampling Strategies.
Article in The AAPS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mycophenolate mofetil (MMF), a prodrug rapidly converted to mycophenolic acid (MPA), is widely used after lung transplantation, but fixed-dose therapy is complicated by exposure variability, enterohepatic recirculation, drug interactions, and limited routine use of area under the concentration-time curve (AUC)-guided therapeutic drug monitoring (TDM). Volumetric absorptive microsampling (VAMS) may support less invasive sampling, including later sampling windows relevant to enterohepatic recirculation. This prospective exploratory cohort study enrolled Taiwanese lung transplant recipients receiving MMF for more than three days. MPA concentrations were collected using VAMS at eight time points over a 12-hour dosing interval. Full-profile AUC
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