ArticleJournal of imaging informatics in medicine2026
A Novel Approach to Evaluating the Synergistic Effect of Curcumin and Cisplatin on Breast Cancer Cells: AgNORs Staining Based on Machine Learning.
Article in Journal of imaging informatics in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cisplatin, an antineoplastic drug commonly used to treat many solid tumors, has serious side effects that limit its clinical use. Therefore, combination therapy with curcumin may be a good option to increase efficacy. The number, size, and distribution of Argyrophilic Nucleolar Organizing Regions (AgNORs) in the nucleus are useful in tumor detection and prognosis; however, since manually determining AgNORs is time-consuming and error-prone, a method that allows for accurate and rapid determination is crucial. In this study, we aimed to evaluate the antiproliferative effects of curcumin and cisplatin combinations on breast cancer cells by analyzing AgNOR staining using machine learning methods. Therefore, we determined the IC
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