Evidence map›Paper›PMID 42760406›Full record

ArticleNeuroradiology2026

Pipeline Shield versus Pipeline Flex for unruptured intracranial aneurysms: a propensity-matched multicenter study.

Runze Ge, Chao Peng, Wenxin Chen, Guangzhong Chen, Can Li, Peifeng Guan, Lele Dai, Zhuohua Wen, Chi Huang, Jiwan Huang and 13 more

Registry-linked trialAbstract read
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Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06446778 (Pipeline Embolization Device for Intracranial Aneurysm), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06446778 recruitingnot on this map

Pipeline Embolization Device for Intracranial Aneurysm (PEDIA): a Prospective, Multicenter Cohort Focus on Safety, Efficacy, and Haemodynamics

Typeobservational_patient_registrySponsorZhujiang HospitalRan2022 to 2030Enrolled1,000ConditionsEfficacy, Self, Hemodynamic Instability, Stenosis, Aneurysm, IntracranialArmsPipeline embolization device with or without shield technique
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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

23 authors.

Runze Ge *Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID http://orcid.org/0009-0002-0778-1199
Chao Peng *Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Wenxin Chen *Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Guangzhong ChenDepartment of Neurosurgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-7318-5259
Can LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0000-0003-3497-4463
Peifeng GuanDepartment of Neurosurgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0002-7981-9977
Lele DaiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0009-0009-8405-7381
Zhuohua WenNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Chi HuangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0009-0003-9134-3921
Jiwan HuangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Jiancheng LinNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Mengshi HuangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0009-0009-7115-9688
Hao YuanNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0009-0004-8957-0508
Fengying YuanNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Yushan WangInterventional Therapy Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yiming BiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Shixing SuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0009-0000-8539-208X
Xin ZhangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0000-0002-1007-4180
Xifeng LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.ORCID https://orcid.org/0000-0003-4393-1916
Aihua LiuNeurointervention Center, Beijing Tian Tan Hospital, Beijing, China. liuaihuadoctor@163.com.
Shuyin LiangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. lsy0925@126.com.
Chuanzhi DuanNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. doctor_duanZJ@163.com.ORCID https://orcid.org/0000-0002-2025-8637
Xin FengNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. 13681134001@163.com.

Funding

Clinical Research Program of Southern Medical University dxlcyj0001Natural Science Foundation of China 82571457Natural Science Foundation of China 82571671Natural Science Foundation of China 82571691the Foundation of National Health Commission Capacity Building and Continuing Education Center GWJJ2022100102the Foundation of National Health Commission Capacity Building and Continuing Education Center GWJJQ2022100104the Foundation of National Health Commission Capacity Building and Continuing Education Center GWJJQ2023100101
6 · The paper itself

Abstract

backgroundPipeline Flex Embolization Device with Shield Technology (PED Shield) is designed to reduce the incidence of thrombosis events through phosphorylcholine coating. However, the comparative efficacy and safety of PED Shield and PED/PED Flex remain unclear.

methodsWe conducted a retrospective analysis of a prospectively maintained database at three advanced stroke centers from February 2016 to October 2024. Propensity score matching was employed to adjust for sex, age, hypertension, diabetes, hyperlipidemia, smoking, aneurysm location, morphology, size, coiling and follow-up duration. After matching, perioperative complications and clinical and angiographic outcomes were compared.

results1039 patients treated by PED/PED Flex and 172 patients treated by PED Shield were enrolled. For clinical outcomes, 164 pairs were matched. No significant differences were found in total perioperative complications (7.9% vs. 4.9%, p = 0.259) and favourable prognosis (mRS score 0-2, 98.0% vs. 97.5%, p = 0.760) between the PED Shield and PED/PED Flex group. For angiographic outcomes, 121 pairs were matched. No significant differences were observed in complete occlusion (80.2% vs. 73.6%, p = 0.223), significant in-stent stenosis (ISS, ISS rate > 50%) (3.3% vs. 5.0%, p = 0.749) and symptomatic ISS (0.0% vs. 2.5%, p = 0.247) between the PED Shield and PED/PED Flex group. However, PED Shield had a lower incidence of ISS (ISS rate ≥ 25%, 5.0 vs. 14.9%, p = 0.010) at a mean follow-up time of 6-7 months.

conclusionCompared with PED/PED Flex, PED Shield has a lower rate of ISS at a mean follow-up time of 6-7 months. No significant differences are observed in perioperative complications, clinical outcomes, complete occlusion, significant ISS and symptomatic ISS. REGISTRATION: URL: https://www. CLINICALTRIALS: gov ; Unique identifier: NCT06446778.

Indexed as

Flow diversionIn-stent stenosisPipeline Flex Embolization Device with Shield TechnologyPropensity score matching

Identifiers

PMID42760406

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