Evidence map›Paper›PMID 42760315›Full record

ArticleNature metabolism2026

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Dario F De Jesus, Natalie K Brown, Garrett Fogarty, Guilherme Gabriel, Shirong Wang, Shen Wang, Lenee Shrestha, Kristin Kendall, Lily Young, Jiang Hu and 5 more

Abstract read
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dario F De Jesus *Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA. DarioFDeJesus@uchicago.edu.ORCID http://orcid.org/0000-0001-8826-9095
Natalie K Brown *Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9984-0135
Garrett Fogarty *Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Guilherme GabrielDepartment of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA.
Shirong WangIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Shen WangDepartment of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA.
Lenee ShresthaDepartment of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA.
Kristin KendallIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Lily YoungIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0008-1389-1099
Jiang HuIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Jermaine AustinDepartment of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA.
Joan Sabadell-BasalloteIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3608-1837
Sevim KahramanIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Ling XiaoIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Rohit N KulkarniIslet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA. Rohit.Kulkarni@joslin.harvard.edu.ORCID http://orcid.org/0000-0001-5029-6119

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Role of IGF-1 and Insulin Receptors Beta-Cell SurvivalR01DK067536 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 2004 to 2026
$8.0M
Epitranscriptomics in human obesity and type 2 diabetesRC2DK139552 · NIDDK · JOSLIN DIABETES CENTER · PI Mengjie Chen, CHUAN HE · 2024 to 2026
$6.0M
Interrogation of dynamic RNA modifications in beta cells in type 1 diabetesUC4DK116278 · NIDDK · JOSLIN DIABETES CENTER · PI HE, CHUAN, KULKARNI, ROHIT N. · 2017 to 2017
$1.9M
Interrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetesR00DK135927 · NIDDK · UNIVERSITY OF CHICAGO · PI Dario F De Jesus · 2025 to 2026
$498k
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R00 DK135927NIDDK NIH HHS R01 DK067536NIDDK NIH HHS RC2 DK139552NIDDK NIH HHS UC4 DK116278U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30 DK36836U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R00 DK135927U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01 DK067536U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) RC2 DK139552U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) UC4 DK116278
6 · The paper itself

Abstract

Pancreatic α-cells are central regulators of glucose and amino acid homeostasis, yet the mechanisms that preserve α-cell identity and function remain incompletely understood. N

Indexed as

AdenosineCell PlasticityGlucagon-Secreting CellsRNA, MessengerAnimalsEpitranscriptomeEpitranscriptomicsInsulin-Secreting CellsMethylationMethyltransferasesMiceRNA MethylationAdenosineMethyltransferasesMettl14 protein, mouseN-methyladenosineRNA, Messenger

Identifiers

PMID42760315
PMCPMC13597303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.