Evidence map›Paper›PMID 42760298›Full record

ArticleSignal transduction and targeted therapy2026

An integrated multiomic single-vesicle atlas delineates graft exosome heterogeneity in chronic lung allograft dysfunction.

Dong Tian, Xiangyun Zheng, Zengwei Yu, Dapeng Wang, Weiyang Chen, Yaling Liu, Zehui Liu, Boyang Xia, Xiaohan Jin, Haoji Yan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Dong Tian *Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China. 22tiandong@wchscu.cn.ORCID http://orcid.org/0000-0001-8510-8309
Xiangyun Zheng *Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zengwei YuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Dapeng WangDepartment of Intensive Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, China.
Weiyang ChenDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yaling LiuLung Transplant Research Laboratory, West China Hospital, Sichuan University, Chengdu, China.
Zehui LiuDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Boyang XiaDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Xiaohan JinDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Haoji YanDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ye WuDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yongsheng ZhaoInstitute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0009-0003-1992-0499
Chuanfen ZhangInstitute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Qiang PuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0001-7221-0259
Jingyu ChenWuxi Lung Transplantation Centre, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, China.
Masaaki SatoDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. satom-sur@h.u-tokyo.ac.jp.
Lunxu LiuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China. lunxu_liu@aliyun.com.ORCID http://orcid.org/0000-0003-3964-5378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The underlying mechanisms of exosomes in chronic lung allograft dysfunction (CLAD) remain poorly understood. The primary challenge lies in the substantial functional heterogeneity of exosomes in CLAD. In this study, lung transplantation was initially performed, followed by the generation of a chronic rejection (CR) model in rats to simulate CLAD in humans. Exosomes from lung graft tissues were extracted, purified, and subjected to proximity barcoding assay-based single-vesicle membrane proteomic profiling. Additionally, bulk proteomic and metabolomic profiling of the graft tissues was conducted. Exosomes were categorized into 14 clusters. Compared with the syngeneic group, the CR group had significantly lower levels of clusters 7 (Nphs1

Indexed as

ExosomesGraft RejectionLungLung TransplantationAllograftsAnimalsHumansMaleMultiomicsProteomicsRats

Identifiers

PMID42760298
PMCPMC13588815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.