ArticleOpen heart2026
Prevalence of aortic findings among patients with multifocal fibromuscular dysplasia (FMD) seen at a specialised referral centre.
Article in Open heart, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that affects medium-sized arteries with multifocal (beaded) or focal stenotic lesions, aneurysms, dissections and tortuosity. The extent of aortic involvement in FMD is uncertain. This study evaluates the prevalence and characteristics of aortic findings in patients with multifocal FMD.
methodsSingle-centre, retrospective chart review of patients with multifocal FMD seen from January 2019 to July 2024. Patients ≥18 years with complete aortic cross-sectional imaging were included. Demographic, medical history, family history and vascular phenotype were collected. Aortic pathologies were characterised: aneurysms (thoracic diameter ≥4 cm, abdominal diameter ≥3 cm), ectasia, dissection, stenosis and anatomical anomalies.
resultsOf 360 patients (353 female, 98.1%), aortic involvement was identified in 36 patients (10.0%; 95% CI 7.3% to 13.5%): three acute aortic syndromes (<1%), eight aneurysms (2.2%), 17 ectasias (4.7%) and nine congenital anomalies (2.5%). Among those with aortic involvement (n=36), three (8.3%) were male, four (11.1%) had a family history of aneurysm, two (5.6%) had a family history of dissection and nine underwent clinical genetic testing for aortopathies, all of which were negative. All aortic aneurysms and ectasias were in the proximal thoracic aorta (eight aortic root, 17 ascending aorta). No aortic stenosis was found. Of the nine congenital anomalies, seven had an aberrant right subclavian artery, one had ductus diverticulum and one had coarctation. Compared with patients without aortic involvement, those with aortic involvement were more likely to be male and have non-aortic arterial aneurysms.
conclusionAortic findings, predominantly presenting as thoracic ectasia or aneurysm, were identified in 10% of patients with multifocal FMD and complete aortic imaging seen at a single specialised referral centre. These findings support recommendations for head-to-pelvis imaging for patients with FMD and highlight the need for further research into the genetic and systemic aspects of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.