Evidence map›Paper›PMID 42760069›Full record

ArticleBMJ open2026

Multicentre, 2×2 factorial, randomised, open-label trial of neuromodulators and cough control therapy for refractory or unexplained chronic cough: the FORTITUDE trial protocol.

Elena Kum, Wafa Hassan, Sue Beaudin, Geoff Strong, Kim Smith, Ana Oliveira, Mustafa Al-Saiedy, Renata Mancopes, Ana Sofia Grave, Melanie Bernier and 12 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07288528 (A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07288528 phase4not yet recruitingnot on this map

A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough (FORTITUDE)

TypeinterventionalSponsorMcMaster UniversityRan2026 to 2029Enrolled124ConditionsCough, Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity SyndromeArmsMorphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin, Pregabalin + Cough Control Therapy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Elena KumDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6548-2632
Wafa HassanDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Sue BeaudinDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Geoff StrongDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Kim SmithDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Ana OliveiraRespiratory Research and Rehabilitation Laboratory (Lab3R), School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal.
Mustafa Al-SaiedyDepartment of Medicine, University of Calgary, Calgary, Alberta, Canada.
Renata MancopesSwallowing Rehabilitation Research Laboratory, KITE Research Institute, Toronto, Ontario, Canada.
Ana Sofia GraveRespiratory Research and Rehabilitation Laboratory (Lab3R), School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal.
Melanie BernierDepartment of Medicine, Laval University, Québec City, Quebec, Canada.
Anurag BhallaDepartment of Medicine, Western University, London, UK, Canada.
Danica L BristerDepartment of Medicine, University of Calgary, Calgary, Alberta, Canada.
Andréanne CôtéDepartment of Medicine, Laval University, Québec City, Quebec, Canada.
Simon CouillardFaculté de médecine et des sciences de la santé, Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
Stephen K FieldDepartment of Medicine, University of Calgary, Calgary, Alberta, Canada.
Faye JohnstonChronic Cough Canada, Hamilton, Ontario, Canada.
Robert NewmanChronic Cough Canada, Hamilton, Ontario, Canada.
Nada PopovicChronic Cough Canada, Hamilton, Ontario, Canada.
Alan G KaplanFamily Physicians Airway Group of Canada, Markham, Ontario, Canada.
Dina BrooksSchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Gordon GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Imran SatiaDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada satiai@mcmaster.ca.ORCID http://orcid.org/0000-0003-4206-6000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile clinicians commonly prescribe neuromodulators for the treatment of refractory or unexplained chronic cough, no trials have directly compared these treatments. Furthermore, although guidelines recommend non-pharmacological management involving physiotherapy and speech-language therapy, few trials have evaluated its effectiveness. METHODS AND ANALYSIS: FORTITUDE ( ETHICS AND DISSEMINATION: Health Canada's Pharmaceutical Drugs Directorate has provided approval to conduct this study. We have approval from the Hamilton Integrated Research Ethics Board of the Main Coordinating Site, with ethics pending at other participating sites. Results of the main trial and the observational extension will be published as manuscripts in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT07288528.

Indexed as

Chronic CoughCoughMorphineNeurotransmitter AgentsPregabalinAdultCanadaFemaleHumansMaleMulticenter Studies as TopicQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeMorphineNeurotransmitter AgentsPregabalinClinical ProtocolsPulmonary DiseaseRandomized Controlled Trial

Identifiers

PMID42760069
PMCPMC13599969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.