ArticleKidney international2026
Cadherin-11 and the mechanobiology of the fibrogenic niche.
Article in Kidney international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
Cadherin-11 has been proposed as a biomarker of kidney fibrosis, but whether it drives disease was unclear. Huffstater et al. show that genetic or antibody blockade of cadherin-11 limits fibrosis, preserves renal function, and prevents stiffening of the fibrogenic niche across 3 injury models. The authors argue that cadherin-11 affects fibroblasts, leading to their activation by reinforcing the cell's force-generating machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.