Evidence map›Paper›PMID 42759971›Full record

Observational studyBMJ health & care informatics2026

Did you miss me? Making the most of digital phenotyping data by imputing missingness with point process models: observational study.

Imogen E Leaning, Andrea Costanzo, Raj Jagesar, Loran Knol, Sarah Tjeerdsma, Anna Tyborowska, Nessa Ikani, Lianne M Reus, Pieter Jelle Visser, Martien Jh Kas and 3 more

Abstract readObservational Study
In one paragraph

Observational study in BMJ health & care informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Comparing training window selection methods for prediction in non-stationary time series.The British journal of mathematical and statistical psychology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Imogen E LeaningDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4264-6585
Andrea CostanzoGroningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Raj JagesarGroningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Loran KnolDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Sarah TjeerdsmaDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Anna TyborowskaDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Nessa IkaniDepartment of Developmental Psychology, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.
Lianne M ReusDepartment of Neurology, Alzheimer Center, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.
Pieter Jelle VisserDepartment of Neurology, Alzheimer Center, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.
Martien Jh KasGroningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Christian F BeckmannDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Henricus G RuhéDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Andre F MarquandDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands andre.marquand@donders.ru.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSmartphone-based digital phenotyping can provide low-burden behavioural measures for mental disorder monitoring. However, progress in making inferences from these data is challenged by the common occurrence of missing data. We propose a method to impute missingness using non-homogeneous Poisson point process models (PPPMs), where activities (overall phone, social media, communication app usage, outgoing/incoming calls) are modelled as 'points'.

methodsWe evaluate personalised PPPMs for imputation and investigate their influence on downstream analysis. In a ground truth evaluation (in and out-of-sample), we evaluate time-varying covariates ('hour of the day', 'day of the week'; encoded using one-hot encoding and sine-cosine transformation) to model behavioural patterns in participants from SMARD (depression; n=26). We train a hidden Markov model (HMM) on data simulated by the PPPMs and compare this to a ground truth HMM. We then perform a replication of a prior HMM analysis in PRISM (Alzheimer's disease, schizophrenia, healthy controls; n=65) and Hersenonderzoek studies (Alzheimer's disease, memory complaints, healthy controls; n=283).

resultsIn the ground truth evaluation, 'hour' was consistently significant in in-sample likelihood ratio tests and 'day' was less commonly significant. PPPMs including one-hot encoded hour generally provided the highest out-of-sample likelihood. Using this PPPM variant, HMM properties were preserved, and prior findings were replicated. DISCUSSION: Personalised PPPMs provide behavioural simulations that can be used for temporal imputation. These models capture average patterns and could be extended to include further temporal components.

conclusionNon-homogeneous PPPMs are a promising imputation tool that may contribute to improved utility of digital phenotyping by providing realistic temporal imputations.

Indexed as

PhenotypeSmartphoneAlzheimer DiseaseDigital MediaHidden Markov ModelsHumansPoisson DistributionComputing MethodologiesData ScienceSmartphone

Identifiers

PMID42759971
PMCPMC13636317

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.