ArticleCell metabolism2026
Glutamine metabolism as a rheostat of CD4
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Article in Cell metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
24 authors.
Keisuke SawadaDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jarren R OatesDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Masaki KimuraDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Traci E StankiewiczDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
John EomDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Pablo C AlarconDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Hak ChungDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Michelle S M A DamenDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Cassidy J UlanowiczDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jennifer L WaylandDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Ethan S O Williams FonnerSummer Undergraduate Research Fellowship Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Colin C AndersonDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Hayde K Cuervo-JimenezPathobiology and Molecular Medicine Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Amelia M PearsonDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Yunguan WangDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Autoimmune Liver Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Nathan SalomonisDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Ty D TroutmanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jeffrey C RathmellBen May Department for Cancer Research and Ludwig Center at the University of Chicago, Chicago, IL 60637, USA.
Sara SzaboDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Michael A HelmrathDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Stem Cell & Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Takanori TakebeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Graduate School of Medicine and Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka, Suita, Osaka 565-0871, Japan; Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), Bunkyo-ku, Tokyo 113-8510, Japan; Center for Stem Cell & Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Maria E Moreno-FernandezDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Senad DivanovicDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: senad.divanovic@cchmc.org.
Funding
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MTissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Matthew Tyson Weirauch · 2016 to 2026
$7.7MImmunopathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK099222 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Senad Divanovic · 2013 to 2026
$5.6MPatient-specific, combinatorial NAMs for gastrointestinal diseases and drug response predictionUM1TR006070 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON, Emily Miraldi · 2026 to 2026
$3.2MRole of apoE in HDL-mediated enhanced survival of human regulatory T-cellsR01HL167200 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI W Sean Davidson, AMY SANGHAVI SHAH · 2023 to 2026
$2.6MEngineering multi-organs in a dishDP2DK128799 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI TAKEBE, TAKANORI · 2020 to 2020
$2.3MOrganoid-guided Precision Hepatology for SteatohepatitisR01DK135478 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Takanori Takebe · 2024 to 2026
$1.6MPeroxisomal control of CD4+ T cell inflammatory responsesR21AI200165 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Senad Divanovic, Maria Eugenia Fields (n,e Moreno-Fernandez) · 2026 to 2026
$203kNCATS NIH HHS UM1 TR006070NHLBI NIH HHS R01 HL167200NIAID NIH HHS R21 AI200165NIAMS NIH HHS P30 AR070549NIDDK NIH HHS DP2 DK128799NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK099222NIDDK NIH HHS R01 DK135478
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) severity is independently linked with pathogenic CD4
Indexed as
CD4-Positive T-LymphocytesGlutamineNon-alcoholic Fatty Liver DiseaseAnimalsDisease Models, AnimalHumansLiverMaleMiceMice, Inbred C57BLGlutamineadaptive immunityamino acid metabolismimmunometabolismMASHMASLMASLDNAFLNAFLDNASHobesity
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.