In one paragraphObservational study in Hepatology communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
24 authors.
Cara L MackDivision of Pediatric Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Medical College of Wisconsin, Children's Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-5760-3836 Alexander G MiethkeDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0003-1395-9475 Kieran HawthorneArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Simon HorslenDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-5949-7363 Estella M AlonsoDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-4056-7752 Nitika A GuptaDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Shikha S SundaramSection of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Rohit KohliDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.ORCID 0000-0002-0198-7703 Molly BozicDivision of Gastroenterology and Hepatology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-3644-5381 Mark DeneauDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Intermountain Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-0459-9404 Stephen GutheryDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Intermountain Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-1484-301 Kathleen M LoomesDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1539-6672 Pamela L ValentinoDivision of Gastroenterology and Hepatology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.ORCID 0000-0002-8227-2004 Mary Elizabeth M TessierDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-0341-5442 Benjamin ShneiderDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-7208-0949 John C MageeDepartment of Surgery, Section of Transplant Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-8416-7905 Saul KarpenStravitz-Sanyal Institute for Metabolic Health and Liver Disease, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0002-3379-7592 Phillip RosenthalDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Kasper WangDivision of General and Thoracic Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0487-6416 Amanda RicciutoDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9538-3005 Ronald J SokolSection of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0001-7433-4095 Binita M KamathDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9982-5023 Childhood Liver Disease Research Network (ChilLDReN)
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MNIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MColorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7MChildhood Liver Disease Research Network Data Coordinating CenterU24DK062456 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN C MAGEE · 2019 to 2026
$18.9MEtiology and Treatment of Biliary Atresia and INHU01DK062453 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI RONALD J. SOKOL · 2002 to 2026
$13.5MClinical Center for Cholestatic Liver Disease in ChildrenU01DK062497 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2002 to 2026
$13.2MVCU-Atlanta Center for the Childhood Liver Disease Research Network (ChiLDReN)U01DK062470 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAUL J. KARPEN · 2005 to 2026
$12.7MMid-Atlantic BANH Consortium SiteU01DK062481 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Binita Maya Kamath, Kathleen Mary Loomes · 2002 to 2026
$9.2MMacrophage Cell Subset Specific Biomarkers for Disease Prognosis in Biliary AtresiaU01DK062436 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ALONSO, ESTELLA M. · 2002 to 2023
$7.0MThe Pittsburgh Cholestatic Liver Disease ConsortiumU01DK062466 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HORSLEN, SIMON · 2002 to 2023
$6.3MContinuation of ChiLDReN, the Childhood Liver Disease Research Network: Indiana UniversityU01DK084536 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOLLESTON, JEAN PAPPAS · 2009 to 2023
$5.9MContinuation of the Childhood Liver Disease Research Network Seattle Clinical CenterU01DK084575 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Pamela Valentino · 2009 to 2026
$5.2MNCATS NIH HHS UL1 TR001878NCATS NIH HHS UL1 TR002535NCATS NIH HHS UM1 TR004399NIDDK NIH HHS U01 DK062436NIDDK NIH HHS U01 DK062453NIDDK NIH HHS U01 DK062466NIDDK NIH HHS U01 DK062470NIDDK NIH HHS U01 DK062481NIDDK NIH HHS U01 DK062497NIDDK NIH HHS U01 DK062500NIDDK NIH HHS U01 DK084536NIDDK NIH HHS U01 DK084538NIDDK NIH HHS U01 DK084575NIDDK NIH HHS U01 DK103140NIDDK NIH HHS U01 DK103149NIDDK NIH HHS U24 DK062456
6 · The paper itselfAbstract
backgroundPrimary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define the natural history of pediatric PSC. The aim of this report is to characterize the clinical phenotypes of the first 175 children enrolled in the PSC study and to determine correlations of specific phenotypes with clinical and laboratory characteristics.
methodsData collected included a history of inflammatory bowel disease (IBD), autoimmune hepatitis (AIH), laboratories, autoantibodies, liver stiffness measurements (LSM), medications, and IBD activity. Comparison of phenotypes with/without IBD and/or AIH, and small-duct versus large-duct PSC was performed.
resultsThe median age at enrollment was 16.1 years, 60% were male, 78% had large-duct PSC, and the median duration of PSC was 2.2 years. The predominant phenotype was PSC/IBD, and 96% had quiescent/mild IBD. The entire cohort had evidence of mild liver disease based on biochemistries and LSMs; <10% had evidence of portal hypertension. Higher LSMs were associated with elevated liver biochemistries. There were no significant characteristics that differentiated the phenotypes; however, there was more frequent autoantibody positivity in PSC/IBD and higher LSMs in PSC/AIH overlap syndrome.
conclusionsThis prospective cohort of pediatric PSC revealed mild liver disease in the majority. Laboratory biomarkers of liver injury and fibrosis were associated with LSM severity, suggesting LSM as a reliable tool to monitor PSC progression. This dataset encompasses a well-phenotyped cohort of children with PSC that will be followed prospectively for longitudinal assessment of progression of disease, as well as a model for stratification within future treatment trials.
Indexed as
Cholangitis, SclerosingAdolescentAutoantibodiesChildChild, PreschoolDisease ProgressionElasticity Imaging TechniquesFemaleHepatitis, AutoimmuneHumansInflammatory Bowel DiseasesLiverLongitudinal StudiesMalePhenotypeProspective StudiesAutoantibodiesautoantibodyautoimmune hepatitisinflammatory bowel diseaseSCOPE indextransient elastography
Identifiers
PMID42758866
PMCPMC13592951
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