Evidence map›Paper›PMID 42758862›Full record

ArticleEmerging microbes & infections2026

Peripheral human mAb therapy yields modulation of neuroinflammation and long-term functional recovery from lyssavirus infection.

Celeste Huaman, Yan Xu, Nathaniel M Lott, Elise M Santorella, Madeline Rader, Allison M Strazzella, Caitlyn Clouse, Jocelyn M King, Mattie Melnyk, Junping Hong and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Celeste HuamanDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Yan XuDepartment of Veterinary Biosciences, The College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Nathaniel M LottDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Elise M SantorellaDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Madeline RaderDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Allison M StrazzellaDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Caitlyn ClouseDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Jocelyn M KingDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Mattie MelnykDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Junping HongDepartment of Veterinary Biosciences, The College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Lianying YanDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Adrian C PaskeyGenomics and Bioinformatics Department, Naval Medical Research Command - Frederick, Fort Detrick, MD, USA.
Andrea E LuquetteGenomics and Bioinformatics Department, Naval Medical Research Command - Frederick, Fort Detrick, MD, USA.
Francisco MalagonGenomics and Bioinformatics Department, Naval Medical Research Command - Frederick, Fort Detrick, MD, USA.
Regina Z CerGenomics and Bioinformatics Department, Naval Medical Research Command - Frederick, Fort Detrick, MD, USA.
Kimberly A Bishop-LillyGenomics and Bioinformatics Department, Naval Medical Research Command - Frederick, Fort Detrick, MD, USA.
Daniel P PerlDoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University, Bethesda, MD, USA.
Christopher C BroderDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Kai XuDepartment of Veterinary Biosciences, The College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Brian C SchaeferDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.

Funding

RP5: Nanobody therapeutics against henipaviruses, arenaviruses, and structural characterizationU19AI181930 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRODER, CHRISTOPHER C, GEISBERT, THOMAS WILLIAM · 2024 to 2024
$46.4M
Project 3 - USUHSU19AI142764 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI BRODER, CHRISTOPHER C · 2019 to 2023
$24.6M
Targeting glycoprotein (G) domain-III for pan-lyssavirus nanobody therapeuticsUH2AI171611 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XU, KAI · 2023 to 2024
$423k
NIAID NIH HHS U19 AI142764NIAID NIH HHS U19 AI181930NIAID NIH HHS UH2 AI171611
6 · The paper itself

Abstract

Rabies is a fatal encephalitis caused by viruses in the lyssavirus genus. We previously demonstrated that intraperitoneal administration of a single dose of neutralizing human monoclonal antibody (mAb) F11 can protect mice from fatal lyssavirus infection, post-central nervous system (CNS) invasion. However, the molecular basis of F11 neutralization remains unknown. Here, we use structural and functional analyses to define neutralizing activity of F11 and the related mAb, A6. Cryo-electron microscopy (EM) and negative-stain EM reveal that both mAbs bind Domain III of the glycoprotein G, recognizing a prefusion-specific epitope distinct from previously characterized antibodies including RVC20. Binding stabilizes the prefusion state, blocking membrane fusion. We furthermore found that a single dose of either A6 or RVC20 protected animals from mortality induced by Australian bat lyssavirus (ABLV), while promoting substantial long-term functional recovery. Moreover, A6 similarly protected animals from mortality following infection with a currently circulating wild isolate of

Indexed as

Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralLyssavirusNeuroinflammatory DiseasesRabiesRhabdoviridae InfectionsAnimalsBrainCryoelectron MicroscopyFemaleHumansMiceRabies virusAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, Viralbioluminescence imagingcryoelectron microscopylongitudinalLyssavirusmonoclonal antibodypre-clinical researchrabiestranscriptomics

Identifiers

PMID42758862
PMCPMC13637774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.