Evidence map›Paper›PMID 42758828›Full record

ArticleScience advances2026

Cobalt-mediated suppression of IFN-γ-JAK-STAT1 signaling reprograms IDO1-driven immunosuppression for metalloimmunotherapy.

Tianyi Jiang, Xiaowan Huang, Zhixin Wu, Gulinaizaier Abudusaimaiti, Yang Song, Hongtao Duan, Yuping Zhou, Yaoxu Chen, Sitong Du, Hao Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianyi JiangSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.ORCID 0009-0002-7270-7366
Xiaowan HuangDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore.ORCID 0009-0006-9701-0855
Zhixin WuSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.ORCID 0009-0002-4531-476X
Gulinaizaier AbudusaimaitiSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
Yang SongSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
Hongtao DuanSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.ORCID 0009-0008-6743-941X
Yuping ZhouSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
Yaoxu ChenSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.ORCID 0009-0006-4622-7755
Sitong DuSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
Hao ZhangSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.ORCID 0000-0001-7452-2467
Jieying QianSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
Yunjiao ZhangSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.ORCID 0000-0002-6465-7488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal ions are increasingly recognized as regulators of immune function, yet their application in cancer immunotherapy remains underexplored. Here, we identified cobalt ions (Co

Indexed as

CobaltImmunotherapyIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaSignal TransductionSTAT1 Transcription FactorAnimalsCell Line, TumorFemaleHumansImmunosuppression TherapyMiceTumor MicroenvironmentCobaltIDO1 protein, mouseIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaSTAT1 Transcription Factor

Identifiers

PMID42758828
PMCPMC13588167

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.